Author
Affilliation
Abstract
INTRODUCTION: The LIfestyle for BRAin Health (LIBRA) index yields a dementia riskscore based on modifiable lifestyle factors and is validated in Western samples. Weinvestigated whether the association between LIBRA scores and incident dementia ismoderated by geographical location or sociodemographic characteristics.METHODS: We combined data from 21 prospective cohorts across six continents(N = 31,680) and conducted cohort-specific Cox proportional hazard regressionanalyses in a two-step individual participant data meta-analysis.RESULTS: A one-standard-deviation increase in LIBRA score was associated with a21% higher risk for dementia. The association was stronger for Asian cohorts com-pared to European cohorts, and for individuals aged ≤75 years (vs older), thoughonly within the first 5 years of follow-up. No interactions with sex, education, orsocioeconomic position were observed.DISCUSSION: Modifiable risk and protective factors appear relevant for dementia riskreduction across diverse geographical and sociodemographic groups.
Publisher
Willey
Citation
VAN ASBROECK, Stephanie et al. Lifestyle and incident dementia: A COSMIC individual participant data meta-analysis. Alzheimers Dement, 2024. doi.org/10.1002/alz.13846.
ISSN
1552-5260
Notes
Sebastian Köhler Alzheimer Centrum Limburg. Department of Psychiatry and Neuropsychology. Mental Health and Neuroscience. Research Institute. Maastricht University. Maastricht, The Netherlands. Martin P J van Boxtel Alzheimer Centrum Limburg. Department of Psychiatry and Neuropsychology. Mental Health and Neuroscience. Research Institute. Maastricht University. Maastricht, The Netherlands. Darren M Lipnicki Centre for Healthy Brain Ageing. Discipline of Psychiatry and Mental Health. School of Clinical Medicine. University of New South Wales. Sydney, NW, Australia. John D Crawford Centre for Healthy Brain Ageing. Discipline of Psychiatry and Mental Health. School of Clinical Medicine. University of New South Wales. Sydney, NW, Australia. Sergio Luis Blay Department of Psychiatry. Federal University of São Paulo. São Paulo, SP, Brazil. Xiao Shifu Department of Geriatric Psychiatry. Shanghai Mental Health Center. Shanghai Jiao Tong University School of Medicine. Shanghai, China. Tao Wang Department of Geriatric Psychiatry. Shanghai Mental Health Center. Shanghai Jiao Tong University School of Medicine. Shanghai, China/Department of Psychiatry & Affective Disorders Center. Ruijin Hospital. Shanghai Jiao Tong University School of Medicine. Shanghai, China/Alzheimer's Disease and Related Disorders Center. Shanghai Jiao Tong University. Shanghai, China. Ling Yue Department of Geriatric Psychiatry. Shanghai Mental Health Center. Shanghai Jiao Tong University School of Medicine. Shanghai, China. Richard B Lipton Saul R. Korey Department of Neurology. Albert Einstein College of Medicine. Bronx, New York, USA/Department of Epidemiology and Population Health. Albert Einstein College of Medicine. Bronx, New York, USA/Department of Psychiatry and Behavioral Medicine. Albert Einstein College of Medicine. Bronx, New York, USA Mindy J Katz Saul R. Korey Department of Neurology. Albert Einstein College of Medicine. Bronx, New York, USA Carol A Derby Saul R. Korey Department of Neurology. Albert Einstein College of Medicine. Bronx, New York, USA/Department of Epidemiology and Population Health. Albert Einstein College of Medicine. Bronx, New York, USA Maëlenn Guerchet Inserm U1094. IRD UMR270. University Limoges. CHU Limoges. EpiMaCT - Epidemiology of chronic diseases in tropical zone. Institute of Epidemiology and Tropical Neurology. OmegaHealth. Limoges, France. Pierre-Marie Preux Inserm U1094. IRD UMR270. University Limoges. CHU Limoges. EpiMaCT - Epidemiology of chronic diseases in tropical zone. Institute of Epidemiology and Tropical Neurology. OmegaHealth. Limoges, France. Pascal Mbelesso Department of Neurology. Amitié Hospital. Bangui, Central African Republic. Joanna Norton Institute for Neurosciences of Montpellier. University of Montpellier. Inserm, Montpellier, France Karen Ritchie Institute for Neurosciences of Montpellier. University of Montpellier. Inserm, Montpellier, France/Institut du Cerveau Trocadéro. Paris, France. Ingmar Skoog Department of Psychiatry and Neurochemistry. Neuropsychiatric Epidemiology Unit. Institute of Neuroscience and Physiology. Sahlgrenska Academy. University of Gothenburg. Gothenburg, Sweden/ Centre for Ageing and Health. University of Gothenburg. Gothenburg, Sweden/Region Västra Götaland. Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic. Gothenburg, Sweden. Jenna Najar Department of Psychiatry and Neurochemistry. Neuropsychiatric Epidemiology Unit. Institute of Neuroscience and Physiology. Sahlgrenska Academy. University of Gothenburg. Gothenburg, Sweden/Centre for Ageing and Health. University of Gothenburg. Gothenburg, Sweden/Region Västra Götaland. Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic. Gothenburg, Sweden/Department of Clinical Genetics. Section Genomics of Neurodegenerative Diseases and Aging. Vrije Universiteit Amsterdam. Amsterdam UMC, Amsterdam, The Netherlands. Therese Rydberg Sterner Department of Psychiatry and Neurochemistry. Neuropsychiatric Epidemiology Unit. Institute of Neuroscience and Physiology. Sahlgrenska Academy. University of Gothenburg. Gothenburg, Sweden/ Centre for Ageing and Health. University of Gothenburg. Gothenburg, Sweden/Department of Neurobiology. Aging Research Center. Care Sciences and Society. Karolinska Institute and Stockholm University. Stockholm, Sweden. Nikolaos Scarmeas 1st Department of Neurology. Aiginition Hospital. Medical School. National and Kapodistrian University of Athens. Athens, Greece/Department of Neurology. Taub Institute for Research on Alzheimer's Disease and the Aging Brain. Gertrude H. Sergievsky Center. Columbia University. New York, NY, USA. Mary Yannakoulia Department of Nutrition and Dietetics. Harokopio University. Athens, Greece. Themis Dardiotis School of Medicine. University of Thessaly. Larissa, Greece. Elena Rolandi Golgi Cenci Foundation. Milan, Italy/ Department of Brain and Behavioral Sciences. University of Pavia. Pavia, Italy. Annalisa Davin Golgi Cenci Foundation. Milan, Italy Michele Rossi Golgi Cenci Foundation. Milan, Italy Oye Gureje Department of Psychiatry. WHO Collaborating Centre for Research and Training in Mental Health. Neuroscience and Substance Abuse. University of Ibadan. Ibadan, Nigeria. Akin Ojagbemi Department of Psychiatry. College of Medicine University of Ibadan. Ibadan, Nigeria. Toyin Bello Department of Psychiatry. College of Medicine University of Ibadan. Ibadan, Nigeria. Ki Woong Kim Department of Neuropsychiatry. Seoul National University Bundang Hospital. Seongnam, Republic of Korea/Department of Psychiatry. Seoul National University College of Medicine. Seoul, Republic of Korea/Department of Brain and Cognitive Sciences. Seoul National University College of Natural Sciences. Seoul, Republic of Korea. Ji Won Han Department of Neuropsychiatry. Seoul National University Bundang Hospital. Seongnam, Republic of Korea/Department of Psychiatry. Seoul National University College of Medicine. Seoul, Republic of Korea Dae Jong Oh Workplace Mental Health Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Stella Trompet Department of Internal Medicine. section of Gerontology and Geriatrics. Leiden University Medical Center. Leiden, the Netherlands. Jacobijn Gussekloo Department of Internal Medicine. section of Gerontology and Geriatrics. Leiden University Medical Center. Leiden, the Netherlands/Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands. Steffi G Riedel-Heller Institute of Social Medicine. Occupational Health and Public Health. Medical Faculty. University of Leipzig.Leipzig, Germany. Susanne Röhr Institute of Social Medicine. Occupational Health and Public Health. Medical Faculty. University of Leipzig.Leipzig, Germany/Health and Ageing Research Team. School of Psychology. Massey University. Palmerston North, Aotearoa New Zealand/Global Brain Health Institute. Trinity College Dublin. Dublin, Ireland. Alexander Pabst Institute of Social Medicine. Occupational Health and Public Health. Medical Faculty. University of Leipzig.Leipzig, Germany. Suzana Shahar Center for Healthy Ageing & Wellness. Faculty of Health Sciences. University Kebangsaan Malaysia. Kuala Lumpur, Malaysia. Nurul Fatin Malek Rivan Center for Healthy Ageing & Wellness. Faculty of Health Sciences. University Kebangsaan Malaysia. Kuala Lumpur, Malaysia. Devinder Kaur Ajit Singh Center for Healthy Ageing & Wellness. Faculty of Health Sciences. University Kebangsaan Malaysia. Kuala Lumpur, Malaysia. Erin Jacobsen Department of Psychiatry. University of Pittsburgh School of Medicine. Pittsburgh, Pennsylvania, USA. Mary Ganguli Department of Psychiatry. University of Pittsburgh School of Medicine. Pittsburgh, Pennsylvania, USA/Departments of Neurology, and Epidemiology. University of Pittsburgh School of Medicine and School of Public Health. Pittsburgh, PA, USA. Tiffany Hughes Department of Graduate Studies in Health and Rehabilitation Sciences. Bitonte College of Health and Human Services. Youngstown State University. Youngstown, Ohio, USA. Mary Haan Department of Epidemiology and Biostatistics. School of Medicine. University of California San Francisco. San Francisco, CA, USA. Allison E Aiello Columbia Aging Center and the Department of Epidemiology. Mailman School of Public Health. Columbia University. New York, NY, USA. Ding Ding Institute of Neurology. National Center for Neurological Disorders. National Clinical Research Center for Aging and Medicine. Huashan Hospital. Fudan University. Shanghai, China. Qianhua Zhao Institute of Neurology. National Center for Neurological Disorders. National Clinical Research Center for Aging and Medicine. Huashan Hospital. Fudan University. Shanghai, China. Zhenxu Xiao Institute of Neurology. National Center for Neurological Disorders. National Clinical Research Center for Aging and Medicine. Huashan Hospital. Fudan University. Shanghai, China. Kenji Narazaki Center for Liberal Arts. Fukuoka Institute of Technology. Higashi-ku, Fukuoka, Japan. Tao Chen Department of Physical Education, Sports and Health Research Center. Tongji University. Shanghai, China. Sanmei Chen Graduate School of Biomedical and Health Sciences. Hiroshima University. Hiroshima, Japan. Tze Pin Ng Department of Psychological Medicine. Gerontology Research Programme. Yong Loo Lin School of Medicine. National University of Singapore. Singapore, Singapore. Xinyi Gwee Department of Psychological Medicine. Gerontology Research Programme. Yong Loo Lin School of Medicine. National University of Singapore. Singapore, Singapore. Qi Gao Department of Psychological Medicine. Gerontology Research Programme. Yong Loo Lin School of Medicine. National University of Singapore. Singapore, Singapore. Henry Brodaty Centre for Healthy Brain Ageing. Discipline of Psychiatry and Mental Health. School of Clinical Medicine. University of New South Wales. Sydney, NW, Australia. Julian Trollor Centre for Healthy Brain Ageing. Discipline of Psychiatry and Mental Health. School of Clinical Medicine. University of New South Wales. Sydney, NW, Australia/ Department of Developmental Disability Neuropsychiatry. Discipline of Psychiatry and Mental Health. University of New South Wales. Sydney, NW, Australia. Nicole Kochan Centre for Healthy Brain Ageing. Discipline of Psychiatry and Mental Health. School of Clinical Medicine. University of New South Wales. Sydney, NW, Australia. Antonio Lobo Department of Medicine and Psychiatry. Universidad de Zaragoza. Zaragoza, Spain/Instituto de Investigación Sanitaria Aragón. Zaragoza, Spain/Instituto de Salud Carlos III. Madrid, Spain. Javier Santabárbara Instituto de Investigación Sanitaria Aragón. Zaragoza, Spain/Instituto de Salud Carlos III. Madrid, Spain/Department of Public Health, Universidad de Zaragoza, Zaragoza, Spain. Patricia Gracia-Garcia Department of Medicine and Psychiatry. Universidad de Zaragoza. Zaragoza, Spain/Instituto de Investigación Sanitaria Aragón. Zaragoza, Spain/Instituto de Salud Carlos III. Madrid, Spain. Perminder S Sachdev Centre for Healthy Brain Ageing. Discipline of Psychiatry and Mental Health. School of Clinical Medicine. University of New South Wales. Sydney, NW, Australia/Neuropsychiatric Institute. The Prince of Wales Hospital. Sydney, NW, Australia. Kay Deckers Alzheimer Centrum Limburg. Department of Psychiatry and Neuropsychology. Mental Health and Neuroscience. Research Institute. Maastricht University. Maastricht, The Netherlands. for Cohort Studies of Memory in an International Consortium (COSMIC).
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