| Author | Murta, Silvane Maria Fonseca | |
| Author | Santana, Pedro Augusto Lemos | |
| Author | Lapierre, Thibault Joseph William Jacques Dit | |
| Author | Penteado, André Berndt | |
| Author | Hajje, Marissa El | |
| Author | Vinha, Thabata Corazza Navarro | |
| Author | Liarte, Daniel Barbosa | |
| Author | Souza, Mariana Laureano de | |
| Author | Trossini, Gustavo Henrique Goulart | |
| Author | Rezende Júnior, Celso de Oliveira | |
| Author | Oliveira, Renata Barbosa de | |
| Author | Ferreira, Rafaela Salgado | |
| Access date | 2024-06-25T12:23:54Z | |
| Available date | 2024-06-25T12:23:54Z | |
| Document date | 2024 | |
| Citation | MURTA, Silvane Maria Fonseca et al. New drug discovery strategies for the treatment of benznidazole-resistance in Trypanosoma cruzi, the causative agent of Chagas disease. Expert Opinion on Drug Discovery, v. 19, n. 6, p. 741-753, 2024. doi.org/10.1080/17460441.2024.2349155. | en_US |
| ISSN | 1746-0441 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/64640 | |
| Language | eng | en_US |
| Publisher | Taylor & Francis | en_US |
| Rights | restricted access | |
| Subject in Portuguese | Doença de Chagas | en_US |
| Subject in Portuguese | benznidazole | en_US |
| Subject in Portuguese | interação medicamentosa | en_US |
| Subject in Portuguese | formulação medicamentosa | en_US |
| Subject in Portuguese | resistência a remedios | en_US |
| Title | New drug discovery strategies for the treatment of benznidazole-resistance in Trypanosoma cruzi, the causative agent of Chagas disease | en_US |
| Type | Article | |
| Abstract | Introduction: Benznidazole, the drug of choice for treating Chagas Disease (CD), has significant limitations, such as poor cure efficacy, mainly in the chronic phase of CD, association with side effects, and parasite resistance. Understanding parasite resistance to benznidazole is crucial for developing new drugs to treat CD.
Areas covered: Here, the authors review the current understanding of the molecular basis of benznidazole resistance. Furthermore, they discuss the state-of-the-art methods and critical outcomes employed to evaluate the efficacy of potential drugs against T. cruzi, aiming to select better compounds likely to succeed in the clinic. Finally, the authors describe the different strategies employed to overcome resistance to benznidazole and find effective new treatments for CD.
Expert opinion: Resistance to benznidazole is a complex phenomenon that occurs naturally among T. cruzi strains. The combination of compounds that inhibit different metabolic pathways of the parasite is an important strategy for developing a new chemotherapeutic protocol. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo de Genômica Funcional de Parasitos. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmacêuticos. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Química. Uberlândia, MG, Brazil. | en_US |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Farmácia. São Paulo, SP, Brazil. | en_US |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Farmácia. São Paulo, SP, Brazil. | en_US |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Farmácia. São Paulo, SP, Brazil. | en_US |
| Affilliation | Universidade Federal do Piauí. Departamento de Biologia. Teresina, PI, Brasil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Farmácia. São Paulo, SP, Brazil. | en_US |
| Affilliation | Universidade Federal de Uberlândia. Instituto de Química. Uberlândia, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Produtos Farmacêuticos. Belo Horizonte, MG, Brazil. | en_US |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil. | en_US |
| Subject | Chagas disease | en_US |
| Subject | benznidazole | en_US |
| Subject | drug combinations | en_US |
| Subject | drug formulations | en_US |
| Subject | drug resistance | en_US |
| Subject | novel treatments | en_US |
| Embargo date | 2200-12-31 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
