Background: Leishmaniasis are neglected tropical diseases caused by Leishmania, an important public health problem affecting 12 millon people worldwise. Cutaneous leishmaniasis (CL) is the most frequent form of this disease. It was demonstrated from gene expression analysis that miR-193b, miR-671 and TREM-1 in CL lesions correlate in patients with early cure (within 60 days), indicating that these molecules have potential use as prognostic bioindicators. Methods: The study is approved by the Research Ethics Committee. Samples (biopsy and blood) of 21 patients were collected in Corte de Pedra – Bahia. The blood was processed to obtain peripheral blood mononuclear cells. Total RNA was extracted, cDNA was obtained and gene expression was evaluated by RT-qPCR. Results: In these samples, it was possible to profile the expression of miR-193b and TREM-1 in comparison with healthy controls from a non-endemic area. miR193b expression was significantly reduced in patient biopsies compared to controls. Besides, TREM1 expression was significantly increased in biopsies when compared to the healthy control. But, when comparing patients who heal within 59 days of treatment with those who heal after 60 days, there was no statistical difference in the expression profile of miR- 193b and TREM-1. Conclusion: Due to the complexity of the interaction between the host and the pathogen, the immune response can evoke different solutions for the establishment, survival and persistence of the parasite. Studying this diversity is important to define molecules that may indicate the early prognosis of a chronic disease, such as CL. The data reinforce the potential of miRNA and TREM-1 as possible biomarkers of CL patients with shorter healing time. Based on the results obtained, it will be possible to understand the potential of miR-193b, miR-671 and TREM-1 as promising candidates for application in clinical practice in patients with CL caused by L. braziliensis.