| Author | Ramos, Vanessa | |
| Author | Astacio, Guis S-M. | |
| Author | Valle, Antonio Carlos Francesconi do | |
| Author | Macedo, Priscila M. de | |
| Author | Lyra, Marcelo R. | |
| Author | Almeida-Paes, Rodrigo | |
| Author | Oliveira, Manoel M. E. | |
| Author | Zancopé-Oliveira, Rosely M. | |
| Author | Brandão, Luciana G. P. | |
| Author | Quintana, Marcel S. B. | |
| Author | Gutierrez-Galhardo, Maria Clara | |
| Author | Freitas, Dayvison Francis Saraiva | |
| Access date | 2024-07-12T23:17:29Z | |
| Available date | 2024-07-12T23:17:29Z | |
| Document date | 2021 | |
| Citation | RAMOS, Vanessa et al. Bone sporotrichosis: 41 cases from a reference hospital in Rio de Janeiro, Brazil. PLoS Neglected Tropical Diseases, v. 15, n. 3, p. 1-15, Mar. 2021. | en_US |
| ISSN | 1935-2727 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/64962 | |
| Sponsorship | MMEO was supported by Fundação de Amparo à Pesquisa do Rio de Janeiro [FAPERJ] (Grant: JCNE E-26/203.301/2017). RMZ-O was supported in part by Conselho Nacional de Desenvolvimento Científico e Tecnológico [CNPq] (302796/2017-7) and FAPERJ (E-26/202.527/2019). The routine for diagnosis, follow-up, and treatment was provided by INI-Fiocruz. This study was financed in part by the Coordination for the Improvement of Higher Education Personnel (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES) - Finance Code 001. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en_US |
| Language | eng | en_US |
| Publisher | Public Library of Science | en_US |
| Rights | open access | |
| Title | Bonesporotrichosis: 41 cases from a reference hospital in Rio de Janeiro, Brazil | en_US |
| Type | Article | |
| DOI | 10.1371/journal.pntd.0009250 | |
| Abstract | Background: Bone sporotrichosis is rare. The metropolitan region of Rio de Janeiro is hyperendemic for zoonotic sporotrichosis and the bone presentations are increasing. Methods: We studied a retrospective cohort of 41 cases of bone sporotrichosis, diagnosed from 1999-2016. The inclusion criteria was fungal culture isolation from any clinical specimen associated to bone involvement (radiography and/or computed tomography) compatible with fungal osteomyelitis or histopathological findings of bone material compatible with sporotrichosis. Molecular identification was performed when possible. Results: Male patients represented 58.5% of the cases, with a cohort median age of 43 years. Immunosuppressive conditions were present in 68.3% of the patients, mostly HIV coinfection (51.2%). Multifocal bone involvement (more than one anatomical segment) was diagnosed in 61% of the patients, while 39% presented unifocal involvement. The bones of the hands were the most affected (58.5%), followed by the feet (41.5%) and tibia (26.8%). Multifocal group was characterized by a higher proportion of males (p = 0.0045) with immunosuppressive conditions (p = 0.0014). Amphotericin B followed by oral itraconazole was the main treatment, with a median time of 16.7 months (1.5 to 99.2 months), and cure of 53.7% of the patients (84.6% of immunocompetent and 39.3% of immunocompromised patients). Sequelae occurred in 12.2% of the patients-amputations (7.3%) and ankylosis (4.9%), while 22% died in the course of the disease. Sporothrix brasiliensis was the causative agent in all the 9 (22%) performed cases. Conclusions: Bone sporotrichosis is a chronic, challenging condition with prolonged treatment, often with poor results and sequelae. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Pós-Graduação em Medicina Tropical. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Pós-Graduação em Medicina Tropical. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Bone sporotrichosis | en_US |
| Subject | Zoonotic sporotrichosis | en_US |
| Subject | Rio de Janeiro | en_US |
| e-ISSN | 1935-2735 | |
