Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/6500
Title: Thermostability of lytic heterophile antibodies from human sera infected with Schistosoma mansoni and geo-helminths. An immuno-metric statistical analysis
Authors: Chamone, Munir
Atuncar, Gregório Saraiva
Coelho, Paulo Marcos Zach
Affilliation: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica-Imunologia. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Estatística. Belo Horizonte MG, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/Santa Casa de Misericórdia de Belo Horizonte. Belo Horizonte, MG, Brasil
Abstract: Antibody in human sera that induces lysis of sheep erythrocytes in hemolytic assay was investigated. The present study showed that the presence in serum of the thermostable cytolytic anti-sheep red blood cells antibodies is dependent on the Schistosoma mansoni infection, and this is more frequent in adults than in children. The thermostable characteristic of hemolysins in normal sera was not dependent on the presence of Ascaris lumbricoides, Trichuris trichiura or hookworm geo-helminths. Further, thermostable complement-activating heterophile antibodies were noticed in children in association with massive number of S.mansoni eggs. The results were obtained by using the z- and the chi-square tests. The z-test allows us to formulate a one-sided alternative, i.e., a tendency of one of the attributes. On the other hand, the chi-square test analyzes the independence between attributes by using a contingency table. Besides the obtained results being interesting in the field of schistosomiasis mansoni, they can provide a new insight into the use of statistics in medical science.
Keywords: Schistosoma mansoni
Heterophile antibodies
Thermostability
Lytic antibodies
Geo-helminths
Statistical tests
Issue Date: 2006
Citation: CHAMONE, Munir; ATUNCAR, Gregorio Saraiva ; COELHO, Paulo Marcos Zech. Thermostability of lytic heterophile antibodies from human sera infected with Schistosoma mansoni and geo-helminths. An immuno-metric statistical analysis. Rev. Inst. Med. trop. S. Paulo, 48(3):157-165, 2006
ISSN: 0036-4665
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos

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