Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/652
Title: HIV-1 binding and neutralizing antibodies of injecting drug users
Authors: Reis, Elaine Priscilla Ouverney
Teixeira, Sylvia Lopes Maia
Jesus, Carlos Silva de
Hacker, Mariana de Andrea Vilas-Boas
Morgado, Mariza Gonçalves
Bastos, Francisco Inácio Pinkusfeld Monteiro
Bongertz, Vera
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Informação Científica e Tecnológica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Informação Científica e Tecnológica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Abstract: Previous studies have demonstrated a stronger seroreactivity against some synthetic peptides responsible for inducing neutralizing antibodies in injecting drug observed for plasma from the S group (15/23) than from the IDU group(15/47, P = 0.0108. No correlation between neutralization and seroreactivity with the peptides tested was observed. These results suggest that an important factor responsible for the extensive and broad humoral immune response observed in IDU is their infection route. There was very little difference in neutralizing antibody response between the IDU and S groups despite their differences in seroreactivity and health status.
Keywords: HIV-1
Injecting drug users
Antibodies
Neutralization
Issue Date: 2005
Publisher: Brazilian Journal of Medical and Biological Research
Citation: REIS, Elaine Priscilla Ouverney et al. HIV-1 binding and neutralizing antibodies of injecting drug users. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, SP, v. 38, n. 9, p. 1313-1320, 2005.
DOI: 10.1590/S0100-879X2005000900004
ISSN: 0100-879X
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
ICICT - Artigos de Periódicos

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