| Author | Borba, Pedro B. | |
| Author | Lago, Jamile | |
| Author | Lago, Tainã | |
| Author | Pereira, Mariana Araújo | |
| Author | Queiroz, Artur T. L. | |
| Author | Barud, Hernane S. | |
| Author | Carvalho, Lucas P. | |
| Author | Machado, Paulo R. L. | |
| Author | Carvalho, Edgar M. | |
| Author | Oliveira, Camila I. de | |
| Access date | 2024-08-02T17:55:51Z | |
| Available date | 2024-08-02T17:55:51Z | |
| Document date | 2024 | |
| Citation | BORBA, Pedro B. et al. Improved treatment outcome following the use of awound dressings in cutaneous leishmaniasis lesions. Pathogens, v. 13, n. 5, p. 1-10, 2024. | en_US |
| ISSN | 2076-0817 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/65240 | |
| Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT/DT).
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). | en_US |
| Language | eng | en_US |
| Publisher | MDPI | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Leishmania braziliensis | en_US |
| Subject in Portuguese | Lesão de pele | en_US |
| Subject in Portuguese | Antimoniato de meglumina | en_US |
| Subject in Portuguese | Terapia tópica | en_US |
| Subject in Portuguese | Curativo de feridas | en_US |
| Title | Improved treatment outcome following the use of awound dressings in cutaneous leishmaniasis lesions | en_US |
| Type | Article | en_US |
| DOI | 10.3390/ pathogens13050416 | |
| Abstract | Leishmaniasis, caused by Leishmania parasites, is a neglected tropical disease and Cutaneous Leishmaniasis (CL) is the most common form. Despite the associated toxicity and adverse effects, Meglumine antimoniate (MA) remains the first-choice treatment for CL in Brazil, pressing the need for the development of better alternatives. Bacterial NanoCellulose (BNC), a biocompatible nanomaterial, has unique properties regarding wound healing. In a previous study, we showed that use of topical BNC + systemic MA significantly increased the cure rate of CL patients, compared to treatment with MA alone. Herein, we performed a study comparing the combination of a wound dressing (BNC or placebo) plus systemic MA versus systemic MA alone, in CL caused by Leishmania braziliensis. We show that patients treated with the combination treatment (BNC or placebo) + MA showed improved cure rates and decreased need for rescue treatment, although differences compared to controls (systemic MA alone) were not significant. However, the overall time-to-cure was significantly lower in groups treated with the combination treatment (BNC+ systemic MA or placebo + systemic MA) in comparison to controls (MA alone), indicating that the use of a wound dressing improves CL treatment outcome. Assessment of the immune response in peripheral blood showed an overall downmodulation in the inflammatory landscape and a significant decrease in the production of IL-1a (p < 0.05) in patients treated with topical BNC + systemic MA. Our results show that the application of wound dressings to CL lesions can improve chemotherapy outcome in CL caused by L. braziliensis. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil. | en_US |
| Affilliation | Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER Initiative). Salvador, BA, Brasil / Instituto de Pesquisa Clínica e Translacional. UniFTC. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER Initiative). Salvador, BA, Brasil / Instituto de Pesquisa Clínica e Translacional. UniFTC. Salvador, BA, Brasil. | en_US |
| Affilliation | Uniara. Laboratório de BioPolímeros e Biomateriais. Araraquara, SP, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto de Investigação em Doenças Tropicais. Salvador, BA, Brasil. | en_US |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto de Investigação em Doenças Tropicais. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto de Investigação em Doenças Tropicais. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Doenças Tropicais. Salvador, BA, Brasil. | en_US |
| Subject | Leishmania braziliensis | en_US |
| Subject | Skin lesion | en_US |
| Subject | Meglumine antimoniate | en_US |
| Subject | Topical therapy | en_US |
| Subject | Wound dressing | en_US |
| DeCS | Leishmania braziliensis | en_US |
| DeCS | Ferimentos e lesões | en_US |
| DeCS | Antimoniato de meglumina | en_US |
| DeCS | Terapêutica | en_US |
| DeCS | Bandagens | en_US |
