| Author | Santana, Fabiana Covolo de Souza | |
| Author | Querino, Gislaine Aparecida | |
| Author | Camargo, Rodrigo Mendes de | |
| Author | Souza, Vânia Nieto Brito de | |
| Author | Mangilli, Priscila Bettoni Ballalai | |
| Author | Mira, Marcelo Távora | |
| Author | Bezerra, Ohanna Cavalcanti de Lima | |
| Author | Kehdy, Fernanda de Souza Gomes | |
| Author | Visentainer, Jeane Eliete Laguila | |
| Author | Alves, Hugo Vicentin | |
| Author | Jarduli, Luciana Ribeiro | |
| Author | Moraes, Milton Ozório | |
| Author | Marcos, Elaine Valin Camarinha | |
| Author | Latini, Ana Carla Pereira | |
| Access date | 2024-08-06T18:28:15Z | |
| Available date | 2024-08-06T18:28:15Z | |
| Document date | 2021 | |
| Citation | SANTANA, Fabiana Covolo de Souza et al. HLA-DPB1 and HLA-C alleles are associated with leprosy in a brazilian population. Human Immunology, v. 82, p. 11-18, Jan. 2021. | |
| ISSN | 0198-8859 | |
| URI | https://www.arca.fiocruz.br/handle/icict/65271 | |
| Description | Produção científica do Laboratório de Hanseníase. | pt_BR |
| Sponsorship | This work was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo Grant 2009/16873-8. | |
| Sponsorship | CNPq/DECIT Grant 576051/2008-0. | |
| Sponsorship | Fundação Paulista Contra Hanseníase. | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | restricted access | |
| Title | HLA-DPB1 and HLA-C alleles are associated with leprosy in a brazilian population | en_US |
| Type | Article | |
| DOI | 10.1016/j.humimm.2020.10.008 | |
| Abstract | Despite intense efforts, the number of new cases of leprosy has remained significantly high over the past 20 years. Host genetic background is strongly linked to the pathogenesis of this disease, which is caused by Mycobacterium leprae (M. leprae), and there is a consensus that the most significant genetic association with leprosy is attributed to the major histocompatibility complex (MHC). Here, we investigated the association of human leukocyte antigen (HLA) class I and II genes with leprosy in a Brazilian population encompassing 826 individuals from a hyperendemic area of Brazil; HLA typing of class I (-A, -B, -C) and class II (-DRB1, -DQA1, -DQB1, -DPA1, and -DPB1) loci was conducted. Initially, the associations were tested using the chi-square test, with p-values adjusted using the false discovery rate (FDR) method. Next, statistically significant signals of the associations were submitted to logistic regression analyses to adjust for sex and molecular ancestry data. The results showed that HLA-C*08, -DPB1*04, and -DPB1*18 were associated with protective effects, while HLA-C*12 and -DPB1*105 were associated with susceptibility to leprosy. Thus, our findings reveal new associations between leprosy and the HLA-DPB1 locus and confirm previous associations between the HLA-C locus and leprosy. | en_US |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil / Universidade Estadual Paulista "Júlio de Mesquita Filho". Faculdade de Medicina. Botucatu, SP, Brasil. | |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil / Universidade Estadual Paulista "Júlio de Mesquita Filho". Faculdade de Medicina. Botucatu, SP, Brasil. | |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil / Universidade Estadual Paulista "Júlio de Mesquita Filho". Faculdade de Medicina. Botucatu, SP, Brasil. | |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | |
| Affilliation | Pontifícia Universidade Católica do Paraná. Faculdade de Medicina. Curitiba, PR, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Estadual de Maringá. Centro de Ciências da Saúde. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil. | |
| Affilliation | Universidade Estadual de Maringá. Centro de Ciências da Saúde. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil. | |
| Affilliation | Universidade Estadual de Maringá. Centro de Ciências da Saúde. Departamento de Ciências Básicas da Saúde. Laboratório de Imunogenética. Maringá, PR, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil. | |
| Affilliation | Instituto Lauro de Souza Lima. Bauru, SP, Brasil / Universidade Estadual Paulista "Júlio de Mesquita Filho". Faculdade de Medicina. Botucatu, SP, Brasil. | |
| Subject | Leprosy | en_US |
| Subject | HLA | en_US |
| Subject | Mycobacterium leprae | en_US |
| Subject | Genetic susceptibility | en_US |
