| Author | Rincón, Tomás Cervantes | |
| Author | Kapoor, Tania | |
| Author | Keeffe, Jennifer R. | |
| Author | Simonelli, Luca | |
| Author | Hoffmann, Hans-Heinrich | |
| Author | Agudelo, Marianna | |
| Author | Jurado, Andrea | |
| Author | Peace, Avery | |
| Author | Lee, Yu E. | |
| Author | Gazumyan, Anna | |
| Author | Guidetti, Francesca | |
| Author | Cantergiani, Jasmine | |
| Author | Cena, Benedetta | |
| Author | Bianchini, Filippo | |
| Author | Tamagnini, Elia | |
| Author | Moro, Simone G. | |
| Author | Svoboda, Pavel | |
| Author | Costa, Federico | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Ko, Albert Icksang | |
| Author | Fallon, Brian A. | |
| Author | Avila-Rios, Santiago | |
| Author | Reyes-Téran, Gustavo | |
| Author | Rice, Charles M. | |
| Author | Nussenzweig, Michel C. | |
| Author | Bjorkman, Pamela J. | |
| Author | Ruzek, Daniel | |
| Author | Varani, Luca | |
| Author | MacDonald, Margaret R. | |
| Author | Robbiani, Davide F. | |
| Access date | 2024-08-12T17:20:54Z | |
| Available date | 2024-08-12T17:20:54Z | |
| Document date | 2024 | |
| Citation | RINCON, Tomás Cervantes et al. Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses. Cell Reports, v. 43, n. 6, p. 1-18, 25 June 2024. | |
| ISSN | 2639-1856 | |
| URI | https://www.arca.fiocruz.br/handle/icict/65325 | |
| Sponsorship | This work was supported in part by the Swiss Vaccine Research Institute (SVRI) and by a Czech-Swiss collaborative project funded jointly by the Czech Science Foundation (no. GF21-05445L to Daniel Ruzek) and the Swiss National Science Foundation (no. 310030L_196866 to Davide F. Robbiani) and NIH grants U01 AI151698 (United World Antiviral Research Network [UWARN] to Michel C. Nussenzweig and Davide F. Robbiani); P01 AI138938 and U19 AI111825 (to Charles M. Rice, Michel C. Nussenzweig, Pamela J. Bjorkman, Davide F. Robbiani); R01 AI052473, R01 TW009504, and R01 AI174105 (to Albert Icksang Ko); and R21 AI142010 (to Margaret R. MacDonald). The study was also possible thanks to the IRB-Rockefeller University Stavros Niarchos Foundation Partnership for Global Infectious Disease Research supported by the Fondazione Leonardo and was supported in part by a pilot project award (to Margaret R. MacDonald) through grant no. UL1TR001866 from the National Center for Advancing Translational Sciences (NCATS, NIH Clinical and Translational Science Award [CTSA] program), and the Mexican government (Programa Presupuestal P016; Anexo 13 del Decreto del Presupuesto de Egresos de la Federación). | |
| Language | eng | en_US |
| Publisher | Cell Press | |
| Rights | open access | |
| Title | Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses | en_US |
| Type | Article | |
| DOI | 10.1016/j.celrep.2024.114298 | |
| Abstract | Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in tropical areas. In contrast, Powassan virus (POWV), which causes severe neurologic illness, is a flavivirus transmitted by ticks in temperate regions of the Northern hemisphere. We find serologic neutralizing activity against POWV in individuals living in Mexico and Brazil. Monoclonal antibodies P002 and P003, which were derived from a resident of Mexico (where POWV is not reported), neutralize POWV lineage I by recognizing an epitope on the virus envelope domain III (EDIII) that is shared with a broad range of tick- and mosquito-borne flaviviruses. Our findings raise the possibility that POWV, or a flavivirus closely related to it, infects humans in the tropics. | en_US |
| Affilliation | Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland. | |
| Affilliation | The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA. | |
| Affilliation | California Institute of Technology. Division of Biology and Biological Engineering. Pasadena, CA, USA. | |
| Affilliation | Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland. | |
| Affilliation | The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA. | |
| Affilliation | The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA. | |
| Affilliation | The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA. | |
| Affilliation | The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA. | |
| Affilliation | California Institute of Technology. Division of Biology and Biological Engineering. Pasadena, CA, USA / Stanford University. Department of Biology. Stanford, CA, USA | |
| Affilliation | The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA. | |
| Affilliation | The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA. | |
| Affilliation | Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland. | |
| Affilliation | Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland. | |
| Affilliation | Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland. | |
| Affilliation | Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland. | |
| Affilliation | Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland. | |
| Affilliation | Veterinary Research Institute. Brno, Czech Republic / Biology Centre of the Czech Academy of Sciences. Institute of Parasitology. Ceske Budejovice, Czech Republic / Masaryk University. Faculty of Science. Institute of Experimental Biology. Brno, Czech Republic / University of Veterinary Sciences. Faculty of Veterinary Medicine. Department of Pharmacology and Pharmacy. Brno, Czech Republic. | |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. CT, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. CT, USA / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. CT, USA. | |
| Affilliation | Columbia University. New York State Psychiatric Institute. Department of Psychiatry. New York, NY, USA. | |
| Affilliation | National Institute of Respiratory Diseases. Mexico City, CP, Mexico. | |
| Affilliation | National Institute of Respiratory Diseases. Mexico City, CP, Mexico / Ministry of Health. Coordination of the National Institutes of Health and High Specialty Hospitals. Mexico City, CP, Mexico. | |
| Affilliation | The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA. | |
| Affilliation | The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA / The Rockefeller University. Howard Hughes Medical Institute. New York, NY, USA. | |
| Affilliation | California Institute of Technology. Division of Biology and Biological Engineering. Pasadena, CA, USA. | |
| Affilliation | Veterinary Research Institute. Brno, Czech Republic / Institute of Parasitology. Biology Centre of the Czech Academy of Sciences. Ceske Budejovice, Czech Republic / Masaryk University. Faculty of Science. Institute of Experimental Biology. Brno, Czech Republic. | |
| Affilliation | Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland. | |
| Affilliation | Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland. | |
| Affilliation | The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA. | |
| Affilliation | Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland. | |
| Subject | Antibodies | en_US |
| Subject | Flaviviruses | en_US |
| Subject | Tick diseases | en_US |
| DeCS | Anticorpos | pt_BR |
| DeCS | Flavivírus | pt_BR |
| DeCS | Doenças transmitidas por carrapatos | pt_BR |
| e-ISSN | 2211-1247 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 17 Parcerias e meios de implementação | |
