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https://www.arca.fiocruz.br/handle/icict/65325
HUMAN ANTIBODIES IN MEXICO AND BRAZIL NEUTRALIZING TICK-BORNE FLAVIVIRUSES
Author
Rincón, Tomás Cervantes
Kapoor, Tania
Keeffe, Jennifer R.
Simonelli, Luca
Hoffmann, Hans-Heinrich
Agudelo, Marianna
Jurado, Andrea
Peace, Avery
Lee, Yu E.
Gazumyan, Anna
Guidetti, Francesca
Cantergiani, Jasmine
Cena, Benedetta
Bianchini, Filippo
Tamagnini, Elia
Moro, Simone G.
Svoboda, Pavel
Costa, Federico
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Fallon, Brian A.
Avila-Rios, Santiago
Reyes-Téran, Gustavo
Rice, Charles M.
Nussenzweig, Michel C.
Bjorkman, Pamela J.
Ruzek, Daniel
Varani, Luca
MacDonald, Margaret R.
Robbiani, Davide F.
Kapoor, Tania
Keeffe, Jennifer R.
Simonelli, Luca
Hoffmann, Hans-Heinrich
Agudelo, Marianna
Jurado, Andrea
Peace, Avery
Lee, Yu E.
Gazumyan, Anna
Guidetti, Francesca
Cantergiani, Jasmine
Cena, Benedetta
Bianchini, Filippo
Tamagnini, Elia
Moro, Simone G.
Svoboda, Pavel
Costa, Federico
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Fallon, Brian A.
Avila-Rios, Santiago
Reyes-Téran, Gustavo
Rice, Charles M.
Nussenzweig, Michel C.
Bjorkman, Pamela J.
Ruzek, Daniel
Varani, Luca
MacDonald, Margaret R.
Robbiani, Davide F.
Affilliation
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
California Institute of Technology. Division of Biology and Biological Engineering. Pasadena, CA, USA.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA.
The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA.
California Institute of Technology. Division of Biology and Biological Engineering. Pasadena, CA, USA / Stanford University. Department of Biology. Stanford, CA, USA
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Veterinary Research Institute. Brno, Czech Republic / Biology Centre of the Czech Academy of Sciences. Institute of Parasitology. Ceske Budejovice, Czech Republic / Masaryk University. Faculty of Science. Institute of Experimental Biology. Brno, Czech Republic / University of Veterinary Sciences. Faculty of Veterinary Medicine. Department of Pharmacology and Pharmacy. Brno, Czech Republic.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. CT, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. CT, USA / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. CT, USA.
Columbia University. New York State Psychiatric Institute. Department of Psychiatry. New York, NY, USA.
National Institute of Respiratory Diseases. Mexico City, CP, Mexico.
National Institute of Respiratory Diseases. Mexico City, CP, Mexico / Ministry of Health. Coordination of the National Institutes of Health and High Specialty Hospitals. Mexico City, CP, Mexico.
The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA / The Rockefeller University. Howard Hughes Medical Institute. New York, NY, USA.
California Institute of Technology. Division of Biology and Biological Engineering. Pasadena, CA, USA.
Veterinary Research Institute. Brno, Czech Republic / Institute of Parasitology. Biology Centre of the Czech Academy of Sciences. Ceske Budejovice, Czech Republic / Masaryk University. Faculty of Science. Institute of Experimental Biology. Brno, Czech Republic.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
California Institute of Technology. Division of Biology and Biological Engineering. Pasadena, CA, USA.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA.
The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA.
California Institute of Technology. Division of Biology and Biological Engineering. Pasadena, CA, USA / Stanford University. Department of Biology. Stanford, CA, USA
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Veterinary Research Institute. Brno, Czech Republic / Biology Centre of the Czech Academy of Sciences. Institute of Parasitology. Ceske Budejovice, Czech Republic / Masaryk University. Faculty of Science. Institute of Experimental Biology. Brno, Czech Republic / University of Veterinary Sciences. Faculty of Veterinary Medicine. Department of Pharmacology and Pharmacy. Brno, Czech Republic.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. CT, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. CT, USA / Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven. CT, USA.
Columbia University. New York State Psychiatric Institute. Department of Psychiatry. New York, NY, USA.
National Institute of Respiratory Diseases. Mexico City, CP, Mexico.
National Institute of Respiratory Diseases. Mexico City, CP, Mexico / Ministry of Health. Coordination of the National Institutes of Health and High Specialty Hospitals. Mexico City, CP, Mexico.
The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA.
The Rockefeller University. Laboratory of Molecular Immunology. New York, NY, USA / The Rockefeller University. Howard Hughes Medical Institute. New York, NY, USA.
California Institute of Technology. Division of Biology and Biological Engineering. Pasadena, CA, USA.
Veterinary Research Institute. Brno, Czech Republic / Institute of Parasitology. Biology Centre of the Czech Academy of Sciences. Ceske Budejovice, Czech Republic / Masaryk University. Faculty of Science. Institute of Experimental Biology. Brno, Czech Republic.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
The Rockefeller University. Laboratory of Virology and Infectious Disease. New York, NY, USA.
Università della Svizzera italiana. Institute for Research in Biomedicine. Bellinzona, Switzerland.
Abstract
Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in tropical areas. In contrast, Powassan virus (POWV), which causes severe neurologic illness, is a flavivirus transmitted by ticks in temperate regions of the Northern hemisphere. We find serologic neutralizing activity against POWV in individuals living in Mexico and Brazil. Monoclonal antibodies P002 and P003, which were derived from a resident of Mexico (where POWV is not reported), neutralize POWV lineage I by recognizing an epitope on the virus envelope domain III (EDIII) that is shared with a broad range of tick- and mosquito-borne flaviviruses. Our findings raise the possibility that POWV, or a flavivirus closely related to it, infects humans in the tropics.
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