| Author | Nelson, Christine E. | |
| Author | Foreman, Taylor W. | |
| Author | Fukutani, Eduardo R. | |
| Author | Kauffman, Keith D. | |
| Author | Sakai, Shunsuke | |
| Author | Fleegle, Joel D. | |
| Author | Gomez, Felipe | |
| Author | NIAID/DIR Tuberculosis Imaging Program | |
| Author | Gould, Sydnee T. | |
| Author | Nouën, Cyril Le | |
| Author | Liu, Xueqiao | |
| Author | Burdette, Tracey L. | |
| Author | Garza, Nicole L. | |
| Author | Lafont, Bernard A. P. | |
| Author | Brooks, Kelsie | |
| Author | Arlehamn, Cecilia S. Lindestam | |
| Author | Weiskopf, Daniela | |
| Author | Sette, Alessandro | |
| Author | Hickman, Heather D. | |
| Author | Buchholz, Ursula J. | |
| Author | Johnson, Reed F. | |
| Author | Brenchley, Jason M. | |
| Author | Oberman, James P. | |
| Author | Quieroz, Artur T. L. | |
| Author | Andrade, Bruno B. | |
| Author | Via, Laura E. | |
| Author | Barber, Daniel L. | |
| Access date | 2024-08-14T14:06:54Z | |
| Available date | 2024-08-14T14:06:54Z | |
| Document date | 2024 | |
| Citation | NELSON, Christine E. et al. IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques. Plos Pathogens, v. 20, n. 7, p. 1-34, 2024. | en_US |
| ISSN | 1553-7374 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/65366 | |
| Sponsorship | Division of Intramural Research NIAI / NIH. | en_US |
| Language | eng | en_US |
| Publisher | Public Library of Science | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | IL-10 | en_US |
| Subject in Portuguese | Célula T | en_US |
| Subject in Portuguese | Célula de memória | en_US |
| Subject in Portuguese | SARS-CoV-2 | en_US |
| Subject in Portuguese | Infecção | en_US |
| Subject in Portuguese | Macacos | en_US |
| Title | IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques | en_US |
| Type | Article | en_US |
| DOI | 10.1371/ journal.ppat.1012339 | |
| Abstract | The regulation of inflammatory responses and pulmonary disease during SARS-CoV-2 infection is incompletely understood. Here we examine the roles of the prototypic pro- and anti-inflammatory cytokines IFNγ and IL-10 using the rhesus macaque model of mild COVID-19. We find that IFNγ drives the development of 18fluorodeoxyglucose (FDG)-avid lesions in the lungs as measured by PET/CT imaging but is not required for suppression of viral replication. In contrast, IL-10 limits the duration of acute pulmonary lesions, serum markers of inflammation and the magnitude of virus-specific T cell expansion but does not impair viral clearance. We also show that IL-10 induces the subsequent differentiation of virus-specific effector T cells into CD69+CD103+ tissue resident memory cells (Trm) in the airways and maintains Trm cells in nasal mucosal surfaces, highlighting an unexpected role for IL-10 in promoting airway memory T cells during SARS-CoV-2 infection of macaques. | en_US |
| Affilliation | T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil. | en_US |
| Affilliation | T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | RNA Viruses Section. Laboratory of Infectious Disease. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | RNA Viruses Section. Laboratory of Infectious Disease. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | SARS-CoV-2 Virology Core. Laboratory of Viral Diseases. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | SARS-CoV-2 Virology Core. Laboratory of Viral Diseases. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | SARS-CoV-2 Virology Core. Laboratory of Viral Diseases. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research. La Jolla Institute for Immunology. La Jolla. California, United States of America. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research. La Jolla Institute for Immunology. La Jolla. California, United States of America. | en_US |
| Affilliation | Center for Infectious Disease and Vaccine Research. La Jolla Institute for Immunology. La Jolla. California, United States of America / Department of Medicine. Division of Infectious Diseases and Global Public Health. University of California, San Diego (UCSD). La Jolla, California, United States of America. | en_US |
| Affilliation | Viral Immunity and Pathogenesis Unit. Laboratory of Clinical Immunology and Microbiology. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | RNA Viruses Section. Laboratory of Infectious Disease. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | SARS-CoV-2 Virology Core. Laboratory of Viral Diseases. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | Holy Cross Germantown Hospital. Affiliate of National Breathe Free Sinus and ENT Center. Frederick Breathe Free Sinus and ENT Center. Frederick, Maryland, United States of America. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Affilliation | Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America / Tuberculosis Research Section. Laboratory of Clinical Infectious Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America / Institute of Infectious Disease & Molecular Medicine and Division of Immunology. Department of Pathology. University of Cape Town. Observatory, South Africa. | en_US |
| Affilliation | T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America. | en_US |
| Subject | IL-10 | en_US |
| Subject | T cell | en_US |
| Subject | Memory cell | en_US |
| Subject | SARS-CoV-2 | en_US |
| Subject | Infection | en_US |
| Subject | Macaques | en_US |
| DeCS | Interleucina-10 | en_US |
| DeCS | Linfócitos T | en_US |
| DeCS | Células T de Memória | en_US |
| DeCS | SARS-CoV-2 | en_US |
| DeCS | Infecções | en_US |
| DeCS | Callicebus | en_US |
