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IL-10 SUPPRESSES T CELL EXPANSION WHILE PROMOTING TISSUE-RESIDENT MEMORY CELL FORMATION DURING SARS-COV-2 INFECTION IN RHESUS MACAQUES
Nelson, Christine E. et al. | Date Issued: 2024
Author
Nelson, Christine E.
Foreman, Taylor W.
Fukutani, Eduardo R.
Kauffman, Keith D.
Sakai, Shunsuke
Fleegle, Joel D.
Gomez, Felipe
NIAID/DIR Tuberculosis Imaging Program
Gould, Sydnee T.
Nouën, Cyril Le
Liu, Xueqiao
Burdette, Tracey L.
Garza, Nicole L.
Lafont, Bernard A. P.
Brooks, Kelsie
Arlehamn, Cecilia S. Lindestam
Weiskopf, Daniela
Sette, Alessandro
Hickman, Heather D.
Buchholz, Ursula J.
Johnson, Reed F.
Brenchley, Jason M.
Oberman, James P.
Quieroz, Artur T. L.
Andrade, Bruno B.
Via, Laura E.
Barber, Daniel L.
Affilliation
T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil.
T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
RNA Viruses Section. Laboratory of Infectious Disease. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
RNA Viruses Section. Laboratory of Infectious Disease. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
SARS-CoV-2 Virology Core. Laboratory of Viral Diseases. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, Maryland, United States of America.
SARS-CoV-2 Virology Core. Laboratory of Viral Diseases. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, Maryland, United States of America.
SARS-CoV-2 Virology Core. Laboratory of Viral Diseases. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, Maryland, United States of America.
Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
Center for Infectious Disease and Vaccine Research. La Jolla Institute for Immunology. La Jolla. California, United States of America.
Center for Infectious Disease and Vaccine Research. La Jolla Institute for Immunology. La Jolla. California, United States of America.
Center for Infectious Disease and Vaccine Research. La Jolla Institute for Immunology. La Jolla. California, United States of America / Department of Medicine. Division of Infectious Diseases and Global Public Health. University of California, San Diego (UCSD). La Jolla, California, United States of America.
Viral Immunity and Pathogenesis Unit. Laboratory of Clinical Immunology and Microbiology. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
RNA Viruses Section. Laboratory of Infectious Disease. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
SARS-CoV-2 Virology Core. Laboratory of Viral Diseases. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, Maryland, United States of America.
Barrier Immunity Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
Holy Cross Germantown Hospital. Affiliate of National Breathe Free Sinus and ENT Center. Frederick Breathe Free Sinus and ENT Center. Frederick, Maryland, United States of America.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Pesquisa Clínica e Translacional. Salvador, BA, Brasil / Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
Division of Intramural Research. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America / Tuberculosis Research Section. Laboratory of Clinical Infectious Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America / Institute of Infectious Disease & Molecular Medicine and Division of Immunology. Department of Pathology. University of Cape Town. Observatory, South Africa.
T lymphocyte Biology Section. Laboratory of Parasitic Diseases. National Institute of Allergy and Infectious Disease. National Institutes of Health. Bethesda, Maryland, United States of America.
Abstract
The regulation of inflammatory responses and pulmonary disease during SARS-CoV-2 infection is incompletely understood. Here we examine the roles of the prototypic pro- and anti-inflammatory cytokines IFNγ and IL-10 using the rhesus macaque model of mild COVID-19. We find that IFNγ drives the development of 18fluorodeoxyglucose (FDG)-avid lesions in the lungs as measured by PET/CT imaging but is not required for suppression of viral replication. In contrast, IL-10 limits the duration of acute pulmonary lesions, serum markers of inflammation and the magnitude of virus-specific T cell expansion but does not impair viral clearance. We also show that IL-10 induces the subsequent differentiation of virus-specific effector T cells into CD69+CD103+ tissue resident memory cells (Trm) in the airways and maintains Trm cells in nasal mucosal surfaces, highlighting an unexpected role for IL-10 in promoting airway memory T cells during SARS-CoV-2 infection of macaques.
Keywords in Portuguese
IL-10
Célula T
Célula de memória
SARS-CoV-2
Infecção
Macacos
 
Keywords
IL-10
T cell
Memory cell
SARS-CoV-2
Infection
Macaques
 
DeCS
Interleucina-10
Linfócitos T
Células T de Memória
SARS-CoV-2
Infecções
Callicebus
 
Publisher
Public Library of Science
Citation
NELSON, Christine E. et al. IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques. Plos Pathogens, v. 20, n. 7, p. 1-34, 2024.
DOI
10.1371/ journal.ppat.1012339
ISSN
1553-7374