| Autor | Bongertz, Vera | |
| Autor | Teixeira, Sylvia Lopes Maia | |
| Autor | Grinsztejn, Beatriz | |
| Autor | Pilotto, Jose Henrique da Silva | |
| Autor | Veloso,Valdiléa G. | |
| Autor | Morgado, Mariza Gonçalves | |
| Autor | Bastos, Francisco Inácio Pinkusfeld Monteiro | |
| Autor | Reis, Elaine Priscilla Ouverney | |
| Data de acesso | 2010-08-23T16:58:36Z | pt_BR |
| Data de acesso | 2010-11-04T14:20:06Z | |
| Data de disponibilização | 2010-11-04T14:20:06Z | |
| Data do publicação | 2005 | |
| Citação | BONGERTZ, Vera et al. Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 1, p. 85-89, Feb. 2005. | en_US |
| ISSN | 0074-0276 | |
| URI | https://www.arca.fiocruz.br/handle/icict/657 | |
| Fomento | Financial support: Faperj E-26/170.409/99, CNPq 33530/2000-0 begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting, WHO, Brazilian Ministry of Health | en_US |
| Idioma | eng | en_US |
| Editor | Fundação Oswaldo Cruz | en_US |
| Direito Autoral | open access | |
| Título | Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals | en_US |
| Tipo do documento | Article | |
| Resumo em Inglês | Anti-human immunodeficiency virus type 1 (HIV-1) “binding antibodies” (antibodies capable of binding to synthetic peptides or proteins) occur throughout HIV-1 infection, are high-titered and highly cross-reactive, as confirmed in this study by analyzing plasma from B and F genotype HIV-1 infected individuals. Plasma from individuals infected with clade F HIV-1 displayed the most frequent cross-reactivity, in high titers, while Bbr plasma showed much higher specificity. Similarly, neutralization of a reference HIV-1 isolate (HIV-1 MN) was more frequently observed by plasma from F than B genotype infected individuals. No significant difference was seen in neutralization susceptibility of primary B, Bbr or F clade HIV-1 by plasma from individuals infected with the classical B (GPGR) or F HIV-1, but Bbr (GWGR) plasma were less likely to neutralize the F genotype primary HIV-1 isolates. The data indicate that both B and F genotype derived vaccines would be equally effective against B and F HIV-1 infection, with a slightly more probable effectiveness for F than B genotype. Although the Bbr variant appears to induce a much more specific humoral immune response, the susceptibility in neutralizing the Brazilian HIV-1 B genotype Bbr variant is similar to that observed with the classical B genotype HIV-1. | en_US |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | en_US |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | en_US |
| Afiliação | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Afiliação | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Afiliação | Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil. | en_US |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | en_US |
| Afiliação | Fundação Oswaldo Cruz. Centro de Informações Científicas e Tecnológicas. Rio de Janeiro, RJ, Brasil. | en_US |
| Afiliação | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | en_US |
| Palavras-chave em inglês | Human Immunodeficiency Virus type 1 | en_US |
| Palavras-chave em inglês | Neutralization | en_US |
| Palavras-chave em inglês | Genotype | en_US |
| Palavras-chave em inglês | Brazil | en_US |
