Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/657
Title: Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals
Authors: Bongertz, Vera
Teixeira, Sylvia Lopes Maia
Grinsztejn, Beatriz Gilda Jegerhorn
Pilotto, Jose Henrique da Silva
Santos, Valdiléa Gonçalves Veloso dos
Morgado, Mariza Gonçalves
Bastos, Francisco Inácio Pinkusfeld Monteiro
Reis, Elaine Priscilla Ouverney
Affilliation: Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia, Instituto Oswaldo Cruz-Fiocruz
Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia, Instituto Oswaldo Cruz-Fiocruz
Instituto de Pesquisa Evandro Chagas-Fiocruz, Rio de Janeiro, RJ
Instituto de Pesquisa Evandro Chagas-Fiocruz, Rio de Janeiro, RJ
Instituto de Pesquisa Evandro Chagas-Fiocruz, Rio de Janeiro, RJ
Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia, Instituto Oswaldo Cruz-Fiocruz
Centro de Informações Científicas e Tecnológicas-Fiocruz, Rio de Janeiro, RJ, Brazil
Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia, Instituto Oswaldo Cruz-Fiocruz
Abstract: Anti-human immunodeficiency virus type 1 (HIV-1) “binding antibodies” (antibodies capable of binding to synthetic peptides or proteins) occur throughout HIV-1 infection, are high-titered and highly cross-reactive, as confirmed in this study by analyzing plasma from B and F genotype HIV-1 infected individuals. Plasma from individuals infected with clade F HIV-1 displayed the most frequent cross-reactivity, in high titers, while Bbr plasma showed much higher specificity. Similarly, neutralization of a reference HIV-1 isolate (HIV-1 MN) was more frequently observed by plasma from F than B genotype infected individuals. No significant difference was seen in neutralization susceptibility of primary B, Bbr or F clade HIV-1 by plasma from individuals infected with the classical B (GPGR) or F HIV-1, but Bbr (GWGR) plasma were less likely to neutralize the F genotype primary HIV-1 isolates. The data indicate that both B and F genotype derived vaccines would be equally effective against B and F HIV-1 infection, with a slightly more probable effectiveness for F than B genotype. Although the Bbr variant appears to induce a much more specific humoral immune response, the susceptibility in neutralizing the Brazilian HIV-1 B genotype Bbr variant is similar to that observed with the classical B genotype HIV-1.
Keywords: human immunodeficiency virus type 1
neutralization
genotype
Brazil
Issue Date: 2005
Publisher: Fundação Oswaldo Cruz
Citation: BONGERTZ, V. et al. Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 1, p. 85-89, Feb. 2005.
ISSN: 0074-0276
Appears in Collections:ICICT - Artigos de Periódicos

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