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PASSIVE IMMUNOTHERAPY OF CYNOMOLGUS MONKEYS WITH ANTI-ROTAVIRUS IGY
Produção científica do Laboratório de Virologia Comparada e Ambiental.
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Abstract
Immunoglobulins Y (IgY) purified from egg yolks of hens represents an attractive, cost-effective alternative for the development of new diagnostic and therapeutic platforms. In this study, we evaluated the therapeutic efficacy of rotavirus-specific IgY in a cynomolgus monkey (Macaca fascicularis) model. Animals were experimentally infected with human rotavirus Group A (RVA), the most common cause of severe acute diarrhoea among young children worldwide. Animals were administered human RVA (3.1 × 10⁷ FFU/mL) by oral gavage, challenged with 2.5 mg of anti-RVA IgY orally, and monitored for five days according to clinical, haematological and biochemical parameters; serum electrolyte levels; viral shedding; and histopathological changes. Immunotherapy with anti-RVA IgY had a protective effect against severe rotavirus-induced enteritis in four of the ten treated monkeys, as evidenced by histopathological findings. Although only one animal had diarrhoea, all but one exhibited virus shedding regardless of the treatment.
Publisher
MDPI
Citation
VASCONCELOS, Gentil Arthur Lins Bentes Mendonça de et al. Passive immunotherapy of Cynomolgus monkeys with anti-rotavirus IgY. Pharmaceuticals, v. 16, n. 9, p. 1-16, 30 Aug. 2024.DOI
10.3390/pharmaceutics16091149ISSN
1424-8247Notes
Produção científica do Laboratório de Desenvolvimento Tecnológico em Virologia.Produção científica do Laboratório de Virologia Comparada e Ambiental.
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