Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/66359
Type
PreprintCopyright
Open access
Sustainable Development Goals
03 Saúde e Bem-Estar05 Igualdade de gênero
10 Redução das desigualdades
17 Parcerias e meios de implementação
Collections
- IFF - Preprint [13]
- INI - Preprint [101]
- IOC - Preprint [148]
Metadata
Show full item record
PERINATAL AND NEONATAL CHIKUNGUNYA VIRUS TRANSMISSION: A CASE SERIES
Chikungunya neonatal
Viremia materna
Comprometimento neurológico
Author
Affilliation
Universidade Federal do Estado do Rio de Janeiro. Hospital Universtário Gaffrée e Guinle. Neonatal Intensive Care Unit. Follow-up Clinic. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Pesquisa Clínica Aplicada. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Hospital Universtário Gaffrée e Guinle. Physiotherapy and Occupational Therapy Clinic. Follow-up Clinic. Rio de Janeiro, RJ, Brasil.
University of California. Institute for the Enviroment and Sustainability. Los Angeles, CA, USA.
Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Departament of Radiology. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Pesquisa Clínica Aplicada. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Estado do Rio de Janeiro. Hospital Universtário Gaffrée e Guinle. Physiotherapy and Occupational Therapy Clinic. Follow-up Clinic. Rio de Janeiro, RJ, Brasil.
University of California. Institute for the Enviroment and Sustainability. Los Angeles, CA, USA.
Universidade Federal Fluminense. Hospital Universitário Antônio Pedro. Departament of Radiology. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.
Abstract
Background: Large-scale epidemics in countries with high birth rates can create a concerning scenario where pregnant people are more likely to transmit the virus. Additionally, increased international mobility has made arboviruses a growing problem for travelers. The increased risk of vertical transmission has been related to maternal viremia near delivery. Such transmission leads to severe infection of newborns and may be associated with subsequent neurological impairment including cerebral palsy. This case series provides an overview of clinical and laboratory findings in pregnant individuals with confirmed CHIKV infection as well as the clinical effects on their newborn emphasizing the severity of neonatal chikungunya. Methods: an ambispective case series enrolled newborns with confirmed exposure to CHIKV in utero or in the neonatal period. Results: during the delivery period, the transmission rate among viremic individuals was approximately 62% (18/29). Fever, irritability, rash, and poor feeding in the first week of life were critical signs of neonatal chikungunya, highlighting its severity. Conclusion: Close monitoring of healthy newborns during the first week of life is essential in areas affected by CHIKV epidemics, and in offspring of pregnant travelers who visited the outbreaks zones. This case series is intended to increase neonatologists’ awareness of the possibility of mother-to-child transmission of CHIKV among newborns with a sepsis-like presentation. Prioritizing CHIKV vaccination for women of childbearing age should also be considered.
Keywords in Portuguese
Transmissão verticalChikungunya neonatal
Viremia materna
Comprometimento neurológico
Share