| Author | Cella, Eleonora | |
| Author | Fonseca, Vagner de Souza | |
| Author | Branda, Francesco | |
| Author | Tosta, Stephane Fraga de Oliveira | |
| Author | Moreno, Keldenn Melo Farias | |
| Author | Silva, Gabriel Rocha Schuab da | |
| Author | Ali, Sobur | |
| Author | Slavov, Svetoslav Nanev | |
| Author | Scarpa, Fabio | |
| Author | Santos, Luciane Amorim | |
| Author | Haddad, Simone Kashima | |
| Author | Wilkinson, Eduan | |
| Author | Tegally, Houriiyah | |
| Author | Mavian, Carla | |
| Author | Borsetti, Alessandra | |
| Author | Caccuri, Francesca | |
| Author | Salemi, Marco | |
| Author | Oliveira, Tulio de | |
| Author | Azarian, Taj | |
| Author | Filippis, Ana Maria Bispo de | |
| Author | Alcantara, Luiz Carlos Júnior | |
| Author | Ceccarelli, Giancarlo | |
| Author | Caruso, Arnaldo | |
| Author | Colizzi, Vittorio | |
| Author | Marcello, Alessandro | |
| Author | Lourenço, José | |
| Author | Ciccozzi, Massimo | |
| Author | Giovanetti, Marta | |
| Access date | 2024-10-14T14:41:14Z | |
| Available date | 2024-10-14T14:41:14Z | |
| Document date | 2024 | |
| Citation | CELLA, Eleonora et al. Integrated analyses of the transmission history of SARS-CoV-2 and its association with molecular evolution of the virus underlining the pandemic outbreaks in Italy, 2019-2023. International Journal of Infectious Diseases, p. 1-30, 9 Oct. 2024. | |
| URI | https://www.arca.fiocruz.br/handle/icict/66504 | |
| Description | Produção científica do Laboratório de Arbovírus e Vírus Hemorrágicos. | pt_BR |
| Sponsorship | This work was founded by the CRP-ICGEB Research Grant 2023 Project CRP/BRA20-03, Contract CRP/23/03. | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | open access | |
| Subject in Portuguese | SARS-CoV-2 | pt_BR |
| Subject in Portuguese | Variante D614G | pt_BR |
| Subject in Portuguese | Itália | pt_BR |
| Subject in Portuguese | Pandemia | pt_BR |
| Subject in Portuguese | Epidemiologia genômica | pt_BR |
| Title | Integrated analyses of the transmission history of SARS-CoV-2 and its association with molecular evolution of the virus underlining the pandemic outbreaks in Italy, 2019-2023 | en_US |
| Type | Preprint | |
| Abstract | Background: Italy was significantly affected by the COVID-19 pandemic, experiencing multiple waves of infection following the sequential emergence of new variants. Understanding the transmission patterns and evolution of SARS-CoV-2 is vital for future preparedness. Methods: We conducted an analysis of viral genome sequences, integrating epidemiological and phylodynamic approaches, to characterize how SARS-CoV-2 variants have spread within the country. Results: Our findings indicate bidirectional international transmission, with Italy transitioning between importing and exporting the virus. Italy experienced four distinct epidemic waves, each associated with a significant reduction in fatalities from 2021 to 2023. These waves were primarily driven by the emergence of VOCs such as Alpha, Delta, and Omicron, which were reflected in observed transmission dynamics and effectiveness of public health measures. Conclusions: The changing patterns of viral spread and variant prevalence throughout Italy's pandemic response underscore the continued importance of flexible public health strategies and genomic surveillance, both of which are crucial for tracking the evolution of variants and adapting control measures effectively to ensure preparedness for future outbreaks. | en_US |
| Affilliation | University of Central Florida. College of Medicine. Burnett School of Biomedical Sciences. Orlando, FL, USA. | |
| Affilliation | Universidade do Estado da Bahia. Departamento de Ciências Exatas e da Terra. Salvador, BA, Brasil. | |
| Affilliation | University of Campus Bio-Medico di Roma. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy. | |
| Affilliation | Universidade Federal de Minas Gerais. Programa Interunidades de Pós-Graduação em Bioinformática. Belo Horizonte, MG, Brasil. | |
| Affilliation | Universidade Federal de Minas Gerais. Programa Interunidades de Pós-Graduação em Bioinformática. Belo Horizonte, MG, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Arbovírus e Vírus Hemorrágicos. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | University of Central Florida. College of Medicine. Burnett School of Biomedical Sciences. Orlando, FL, USA. | |
| Affilliation | University of São Paulo. Ribeirão Preto Medical School. Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brasil / Butantan Institute. São Paulo, SP, Brasil. | |
| Affilliation | University of Sassari. Department of Biomedical Sciences. Sassari, Italy. | |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | |
| Affilliation | University of São Paulo. Ribeirão Preto Medical School. Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brasil. | |
| Affilliation | Stellenbosch University. School of Data Science and Computational Thinking. Centre for Epidemic Response and Innovation. Stellenbosch, South Africa. | |
| Affilliation | Stellenbosch University. School of Data Science and Computational Thinking. Centre for Epidemic Response and Innovation. Stellenbosch, South Africa. | |
| Affilliation | University of Florida. College of Medicine. Immunology and Laboratory Medicine. Department of Pathology. Emerging Pathogens Institute. Gainesville, FL, USA / Global Health Program Smithsonian's National Zoo & Conservation Biology Institute. Washington, DC, USA. | |
| Affilliation | Istituto Superiore di Sanità. National HIV/AIDS Research Center. Rome, Italy. | |
| Affilliation | University of Brescia. Section of Microbiology. Department of Molecular and Translational Medicine. Brescia, Italy. | |
| Affilliation | University of Florida. College of Medicine. Immunology and Laboratory Medicine. Department of Pathology. Emerging Pathogens Institute. Gainesville, FL, USA. | |
| Affilliation | Stellenbosch University. School of Data Science and Computational Thinking. Centre for Epidemic Response and Innovation. Stellenbosch, South Africa. | |
| Affilliation | University of Central Florida. College of Medicine. Burnett School of Biomedical Sciences. Orlando, FL, USA. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Arbovírus e Vírus Hemorrágicos. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | |
| Affilliation | Azienda Ospedaliero Universitaria Policlinico Umberto I. Infectious Diseases Department. Rome, Italy. | |
| Affilliation | University of Brescia. Section of Microbiology. Department of Molecular and Translational Medicine. Brescia, Italy. | |
| Affilliation | University of Rome "Tor Vergata". UNESCO Chair of Interdisciplinary Biotechnology and Bioethics. Roma, Italia. | |
| Affilliation | International Centre for Genetic Engineering and Biotechnology. Laboratory of Molecular Virology. Padriciano, Italy. | |
| Affilliation | Universidade Católica Portuguesa. Faculdade de Medicina. Biomedical Research Center. Lisboa, Portugal. | |
| Affilliation | University of Campus Bio-Medico di Roma. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy. | |
| Affilliation | Universita Campus Bio-Medico di Roma. Department of Sciences and Technologies for Sustainable Development and One Health. Rome, Italy / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Arbovírus e Vírus Hemorrágicos. Rio de Janeiro, RJ, Brasil. | |
| Subject | SARS-CoV-2 | en_US |
| Subject | D614G variant | en_US |
| Subject | Italy | en_US |
| Subject | Pandemic | en_US |
| Subject | Genomic epidemiology | en_US |
| Peer reviewed | Não | |
| Publication status | Não Publicado | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
| xmlui.metadata.dc.subject.ods | 17 Parcerias e meios de implementação | |
