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Sustainable Development Goals
03 Saúde e Bem-Estar09 Indústria, inovação e infraestrutura
17 Parcerias e meios de implementação
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- IOC - Preprint [155]
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INTEGRATED ANALYSES OF THE TRANSMISSION HISTORY OF SARS-COV-2 AND ITS ASSOCIATION WITH MOLECULAR EVOLUTION OF THE VIRUS UNDERLINING THE PANDEMIC OUTBREAKS IN ITALY, 2019-2023
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Abstract
Background: Italy was significantly affected by the COVID-19 pandemic, experiencing multiple waves of infection following the sequential emergence of new variants. Understanding the transmission patterns and evolution of SARS-CoV-2 is vital for future preparedness. Methods: We conducted an analysis of viral genome sequences, integrating epidemiological and phylodynamic approaches, to characterize how SARS-CoV-2 variants have spread within the country. Results: Our findings indicate bidirectional international transmission, with Italy transitioning between importing and exporting the virus. Italy experienced four distinct epidemic waves, each associated with a significant reduction in fatalities from 2021 to 2023. These waves were primarily driven by the emergence of VOCs such as Alpha, Delta, and Omicron, which were reflected in observed transmission dynamics and effectiveness of public health measures. Conclusions: The changing patterns of viral spread and variant prevalence throughout Italy's pandemic response underscore the continued importance of flexible public health strategies and genomic surveillance, both of which are crucial for tracking the evolution of variants and adapting control measures effectively to ensure preparedness for future outbreaks.
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