Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/6661
Title: Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides
Authors: Maciel, Ceres
Oliveira Junior, Vani Xavier de
Fazio, Marcos Antonio
Pimenta, Rafael Nacif
Miranda, Antonio
Pimenta, Paulo Filemon Paolucci
Capurro, Margareth Lara
Affilliation: University of São Paulo. Institute of Biomedical Sciences. Department of Parasitology. São Paulo, SP, Brazil.
Federal University of ABC. Natural and Human Science Center. Santo Andre, SP Brazil.
Federal University of São Paulo. Department of Biophysics. São Paulo, SP, Brazil.
Oswaldo Cruz Foundation. Rene Rachou Institute of Research. Laboratory of Medical Entomology. Belo Horizonte, MG, Brazil.
Federal University of São Paulo. Department of Biophysics. São Paulo, SP, Brazil.
Oswaldo Cruz Foundation. Rene Rachou Institute of Research. Laboratory of Medical Entomology. Belo Horizonte, MG, Brazil.
University of São Paulo. Institute of Biomedical Sciences. Department of Parasitology. São Paulo, SP, Brazil.
Abstract: Plasmodiumspecies are the causative agents of malaria, the most devastating insect-borne parasite of human populations. Finding and developing new drugs for malaria treatment and prevention is the goal of much research. Angiotensins I and II (ang I and ang II) and six synthetic related peptides designated Vaniceres 1-6 (VC1-VC6) were assayedin vivo andin vitro for their effects on the development of the avian parasite,Plasmodium gallinaceum.Ang II and VC5 injected into the thoraces of the insects reduced mean intensities of infection in the mosquito salivary glands by 88% and 76%, respectively. Although the mechanism(s) of action is not completely understood, we have demonstrated that these peptides disrupt selectively the P.gallinaceumcell membrane. Additionally, incubation in vitro of sporozoites with VC5 reduced the infectivity of the parasites to their vertebrate host. VC5 has no observable agonist effects on vertebrates, and this makes it a promising drug for malaria prevention and chemotherapy.
Keywords: Malaria
Plasmodium
Issue Date: 2008
Citation: MACIEL, Ceres et al. Anti-PlasmodiumActivity of Angiotensin II and Related Synthetic Peptides. PLoS ONE, v. 3, n. 9, p. 1-8, 2008.
DOI: 10.1371/journal.pone.0003296
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
90. MACIEL C, DE OLIVEIRA JUNIOR VX.pdf246.15 kBAdobe PDFThumbnail
View/Open



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.