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THE BENEFITS OF EXPORTING: ENGINEERED EXTRACELLULAR VESICLES AS PROMISING VACCINE CANDIDATES AGAINST ENTERIC FEVER
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Abstract in Portuguese
O potencial imunológico das vesículas extracelulares produzidas por bactérias Gram-negativas, as chamadas vesículas de membrana externa (OMVs), pode ser melhorado pela engenharia genética, resultando em vesículas contendo múltiplos imunógenos. O potencial dessa abordagem para o desenvolvimento de uma vacina candidata para febre entérica foi recentemente demonstrado por Gasperini e colegas.
Abstract
The immunological potential of extracellular vesicles produced by Gram-negative bacteria, the so-called outer-membrane vesicles (OMVs), can be improved by genetic engineering, resulting in vesicles containing multiple immunogens. The potential of this approach for the development of a vaccine candidate for enteric fever was recently demonstrated by Gasperini and colleagues.
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