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SERINE PROTEASES AND VACCINES AGAINST LEISHMANIASIS: A DUAL ROLE
Vacina
Imunização intramuscular
Imunização intranasal
Contra-protetor
Proteção
TGF-beta
Vaccine
intramuscular immunization
Intranasal immunization
Counter-protective
Protection
TGF-beta
Author
Affilliation
Abstract in Portuguese
As serina proteases estão envolvidas em vários processos bioquímicos que são essenciais para a biologia de patógenos, incluindo Leishmania sp. Considerando sua importância, surgiu o interesse em serina proteases para o desenvolvimento de vacinas contra leishmaniose. Como alvos, essas enzimas demonstraram um papel duplo em uma vacina contra leishmaniose, tanto protetora quanto contraprotetora, dependendo das condições em que são avaliadas. Neste trabalho, são apresentadas serina proteases ou inibidores delas que têm sido usados como componentes de vacinas para Leishmania sp., visando disseminar o conhecimento adquirido sobre essas proteases e seu potencial em potencial vacina contra leishmaniose.
Abstract
Serine proteases are involved in several biochemical processes that are essential for the biology of pathogens, including Leishmania sp. Considering their importance, an interest in serine proteases for vaccine development against leishmaniasis has been raised. As targets, these enzymes have demonstrated a dual role in a vaccine against leishmaniasis, both protective and a counter-protective, depending on the conditions that they are evaluated. In this work, serine proteases or inhibitors of them that have been used as components of vaccines to Leishmania sp. are presented, aiming to disseminate the knowledge gained about these proteases and their potential in potential vaccine against leishmaniasis.
Keywords in Portuguese
Serina proteasesVacina
Imunização intramuscular
Imunização intranasal
Contra-protetor
Proteção
TGF-beta
Keywords
Serine proteasesVaccine
intramuscular immunization
Intranasal immunization
Counter-protective
Protection
TGF-beta
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