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DISPERSION PATTERNS OF SARS-COV-2 VARIANTS GAMMA, LAMBDA AND MU IN LATIN AMERICA AND THE CARIBBEAN
Gräf, Tiago et al. | Date Issued: 2024
Author
Gräf, Tiago
Martinez, Alexander A
Bello, Gonzalo
Dellicour, Simon
Lemey, Philippe
Colizza, Vittoria
Mazzoli, Mattia
Poletto, Chiara
Cardoso, Vanessa Leiko Oikawa
Silva, Alexandre Freitas
COVIGEN, COVIGEN
Motta, Fernando Couto
Resende, Paola Cristina
Siqueira, Marilda M
Franco, Leticia
Gresh, Lionel
Gabastou, Jean-Marc
Rodriguez, Angel
Vicari, Andrea
Aldighieri, Sylvain
Mendez-Rico, Jairo
Leite, Juliana Almeida
Affilliation
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Gorgas Memorial Institute for Health Studies. Panama City. Panama / National Secretary of Research, Technology and Innovation (SENACYT). National Research System (SNI). Panama City, Panama / University of Panama. Department of Microbiology and Immunology. Panama City, Panama.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Arbovírus e Vírus Hemorrágicos. Rio de Janeiro, RJ, Brasil.
Université Libre de Bruxelles. Spatial Epidemiology Lab (SpELL). Bruxelles, Belgium / University of Leuven. Rega Institute. Department of Microbiology, Immunology and Transplantation. Laboratory for Clinical and Epidemiological Virology. Leuven, Belgium.
University of Leuven. Rega Institute. Department of Microbiology, Immunology and Transplantation. Laboratory for Clinical and Epidemiological Virology. Leuven, Belgium.
Sorbonne Université. Institut Pierre Louis d’Épidémiologie et de Santé Publique. Paris, France.
Sorbonne Université. Institut Pierre Louis d’Épidémiologie et de Santé Publique. Paris, France.
University of Padova. Department of Molecular Medicine. Italy.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Enfermidades Infecciosas Transmitidas por Vetores. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Núcleo de Bioinformática. Recife, PE, Brasil.
COVIGEN
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais. Rio de Janeiro, RJ, Brasil.
Pan American Health Organization. Health Emergencies Department. Infectious Hazards Management Unit. Washington, DC, USA.
Pan American Health Organization. Health Emergencies Department. Infectious Hazards Management Unit. Washington, DC, USA.
Pan American Health Organization. Health Emergencies Department. Infectious Hazards Management Unit. Washington, DC, USA.
Pan American Health Organization. Health Emergencies Department. Infectious Hazards Management Unit. Washington, DC, USA.
Pan American Health Organization. Health Emergencies Department. Infectious Hazards Management Unit. Washington, DC, USA.
Pan American Health Organization. Health Emergencies Department. Infectious Hazards Management Unit. Washington, DC, USA.
Pan American Health Organization. Health Emergencies Department. Infectious Hazards Management Unit. Washington, DC, USA.
Pan American Health Organization. Health Emergencies Department. Infectious Hazards Management Unit. Washington, DC, USA.
Abstract
Latin America and Caribbean (LAC) regions were an important epicenter of the COVID-19 pandemic and SARS-CoV-2 evolution. Through the COVID-19 Genomic Surveillance Regional Network (COVIGEN), LAC countries produced an important number of genomic sequencing data that made possible an enhanced SARS-CoV-2 genomic surveillance capacity in the Americas, paving the way for characterization of emerging variants and helping to guide the public health response. In this study we analyzed approximately 300,000 SARS-CoV-2 sequences generated between February 2020 and March 2022 by multiple genomic surveillance efforts in LAC and reconstructed the diffusion patterns of the main variants of concern (VOCs) and of interest (VOIs) possibly originated in the Region. Our phylogenetic analysis revealed that the spread of variants Gamma, Lambda and Mu reflects human mobility patterns due to variations of international air passenger transportation and gradual lifting of social distance measures previously implemented in countries. Our results highlight the potential of genetic data to reconstruct viral spread and unveil preferential routes of viral migrations that are shaped by human mobility patterns.
Keywords in Portuguese
COVID-19
SARS-CoV-2
Vigilância genômica
Rede Regional de Vigilância Genômica COVID-19 (COVIGEN)
 
Keywords
COVID-19
SARS-CoV-2
 
Genomic surveillance
 
DeCS
COVID-19
SARS-CoV-2
Vigilância em Saúde Pública
 
Publisher
Nature
Citation
GRAF, T. et al. Dispersion patterns of SARS-CoV-2 variants Gamma, Lambda and Mu in Latin America and the Caribbean. Nature Communications, v. 15, n. 1837, p. 1-11, 2024.
DOI
10.1038/s41467-024-46143-9
ISSN
2041-1723
Notes
A rede COVIGEN foi elencada no rol de autores. Supplementary information The online version contains supplementary material available at https://doi.org/10.1038/s41467-024-46143-9.