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CLINICAL PROFILE OF SARS-COV-2 INFECTION: MECHANISMS OF THE CELLULAR IMMUNE RESPONSE AND IMMUNOGENETIC MARKERS IN PATIENTS FROM BRAZIL
Produção científica do Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos.
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Abstract
Objectives: The aim of this study is to evaluate some mechanisms of the immune response of people infected with SARS-CoV-2 in both acute infection and early and late convalescence phases. Methods: This is a cohort study of 70 cases of COVID-19, confirmed by RT-PCR, followed up to 60 days. Plasma Samples and clinical data were. Viral load, blood count, indicators inflammation were the parameters evaluated. Cellular immune response was evaluated by flow cytometry and Luminex immunoassays. Results: In the severe group, hypertension was the only reported comorbidity. Non severe patients have activated memory naive CD4+ T cells. Critically ill patients have central memory CD4+ T cell activation. Severe COVID-19 patients have both central memory and activated effector CD8+ T cells. Non-severe COVID-19 cases showed an increase in IL1 , IL-6, IL-10 and TNF and severely ill patients had higher levels of the cytokines IL-6, IL-10 and CXCL8. Conclusions: The present work showed that different cellular responses are observed according to the COVID-19 severity in patients from Brazil an epicenter the pandemic in South America. Also, we notice that some cytokines can be used as predictive markers for the disease outcome, possibility implementation of strategies effective by health managers.
Publisher
MDPI
Citation
PACHECO, Vanessa da Silveira dos Santos et al. Clinical profile of SARS-CoV-2 infection: mechanisms of the cellular immune response and immunogenetic markers in patients from Brazil. Viruses, v. 15, n. 7, p. 1-13, 23 July 2024.DOI
10.3390/v15071609ISSN
1999-4915Notes
O grupo colaborativo está filiado à Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos). Assessoria Clínica. Rio de Janeiro, RJ, Brasil.Produção científica do Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos.
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