| Author | Batista, Marcos Adriano Carlos | |
| Author | Freitas, Flavio Eduardo dias Araujo | |
| Author | Braga, Daiane Cristina de Assis | |
| Author | Souza, Jaqueline Aparecida de | |
| Author | Antunes, Vagner Roberto | |
| Author | Souza, Gustavo Henrique Bianco de | |
| Author | Santos, Orlando David Henrique dos | |
| Author | Brandão, Geraldo Celio | |
| Author | Kohlhoff, Markus | |
| Author | Ceron, Carla Speroni | |
| Author | Moura, Sandra Aparecida Lima de | |
| Author | Cardoso, Leonardo Máximo | |
| Access date | 2024-12-05T13:23:57Z | |
| Available date | 2024-12-05T13:23:57Z | |
| Document date | 2024 | |
| Citation | BATISTA, Marcos Adriano Carlos et al. Antihypertensive effect of a nanoemulsion of baccharis dracunculifolia leaves extract in sodium-dependent hypertensive rats. Natural Product Research, 1–8. https://doi.org/10.1080/14786419.2024.2397724 | |
| URI | https://www.arca.fiocruz.br/handle/icict/67427 | |
| Language | eng | en_US |
| Publisher | Elsevier | |
| Rights | restricted access | |
| Subject in Portuguese | Baccharis dracunculifolia | pt_BR |
| Subject in Portuguese | Propolis verde | pt_BR |
| Title | Antihypertensive effect of a nanoemulsion of baccharis dracunculifolia leaves extract in sodium-dependent hypertensive rats | en_US |
| Type | Preprint | |
| Abstract | Baccharis dracunculifolia (DC) is an important botanical source of Brazilian green propolis and have many compounds with potential antihypertensive activity. However, little is known about the specific antihypertensive properties of DC, or the mechanisms involved. Here we aimed to chemically characterise an ethanolic DC extract (eDC), test its antihypertensive properties and the involvement of neurogenic mechanisms using an animal model of salt-dependent hypertension. The chemical analysis of the eDC revealed the presence of many antihypertensive compounds. Administering the eDC in a nanoemulsion formulation (25 to 50 mg/kg) effectively normalised blood pressure in hypertensive rats. The result also suggested that neurogenic mechanisms are involved in the antihypertensive action of eDC. The treatment with p-coumaric acid (0.32 to 3 mg/kg), a polyphenol abundant in the eDC, produced no significant antihypertensive effect. The findings indicate that the eDC has antihypertensive properties, and that these effects may be mediated through neurogenic pressor mechanisms. | en_US |
| Affilliation | Department of Biological Sciences. Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazil | |
| Affilliation | Department of Physiology and Biophysics. Instituto de Ciências Biológicas. University of São Paulo, São Paulo, SP, Brazil | |
| Affilliation | Department of Biological Sciences. Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazil | |
| Affilliation | Department of Pharmacology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil | |
| Affilliation | Department of Pharmacy. Pharmacy School. Federal University of Ouro Preto. Ouro Preto, MG, Brazil | |
| Affilliation | Department of Physiology and Biophysics. Instituto de Ciências Biológicas. University of São Paulo, São Paulo, SP, Brazil | |
| Affilliation | Department of Pharmacy. Pharmacy School. University of São Paulo, São Paulo, SP, Brazil | |
| Affilliation | Department of Physiology and Biophysics. Instituto de Ciências Biológicas. University of São Paulo, São Paulo, SP, Brazil | |
| Affilliation | Department of Environmental Engineering. Mines School. Federal University of Ouro Preto. Ouro Preto, MG, Brazil | |
| Affilliation | Department of Biological Sciences. Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazil | |
| Affilliation | Bioactive Natural Products Chemistry Laboratory. Oswaldo Cruz Foundation. René Rachou Institute. Belo Horizonte, MG, Brazil | |
| Affilliation | Department of Biological Sciences. Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazil | |
| Subject | Baccharis dracunculifolia | en_US |
| Subject | Brazilian green propolis | en_US |
| Subject | P-coumaric acid | en_US |
| Subject | Hypertension | en_US |
| Subject | Salt | en_US |
| Embargo date | 3100-12-31 | |
