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ANTIHYPERTENSIVE EFFECT OF A NANOEMULSION OF BACCHARIS DRACUNCULIFOLIA LEAVES EXTRACT IN SODIUM-DEPENDENT HYPERTENSIVE RATS
Batista, Marcos Adriano Carlos et al. | Date Issued: 2024
Author
Batista, Marcos Adriano Carlos
Freitas, Flavio Eduardo dias Araujo
Braga, Daiane Cristina de Assis
Souza, Jaqueline Aparecida de
Antunes, Vagner Roberto
Souza, Gustavo Henrique Bianco de
Santos, Orlando David Henrique dos
Brandão, Geraldo Celio
Kohlhoff, Markus
Ceron, Carla Speroni
Moura, Sandra Aparecida Lima de
Cardoso, Leonardo Máximo
Affilliation
Department of Biological Sciences. Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazil
Department of Physiology and Biophysics. Instituto de Ciências Biológicas. University of São Paulo, São Paulo, SP, Brazil
Department of Biological Sciences. Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazil
Department of Pharmacology. Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil
Department of Pharmacy. Pharmacy School. Federal University of Ouro Preto. Ouro Preto, MG, Brazil
Department of Physiology and Biophysics. Instituto de Ciências Biológicas. University of São Paulo, São Paulo, SP, Brazil
Department of Pharmacy. Pharmacy School. University of São Paulo, São Paulo, SP, Brazil
Department of Physiology and Biophysics. Instituto de Ciências Biológicas. University of São Paulo, São Paulo, SP, Brazil
Department of Environmental Engineering. Mines School. Federal University of Ouro Preto. Ouro Preto, MG, Brazil
Department of Biological Sciences. Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazil
Bioactive Natural Products Chemistry Laboratory. Oswaldo Cruz Foundation. René Rachou Institute. Belo Horizonte, MG, Brazil
Department of Biological Sciences. Institute of Exact and Biological Sciences. Federal University of Ouro Preto. Ouro Preto, MG, Brazil
Abstract
Baccharis dracunculifolia (DC) is an important botanical source of Brazilian green propolis and have many compounds with potential antihypertensive activity. However, little is known about the specific antihypertensive properties of DC, or the mechanisms involved. Here we aimed to chemically characterise an ethanolic DC extract (eDC), test its antihypertensive properties and the involvement of neurogenic mechanisms using an animal model of salt-dependent hypertension. The chemical analysis of the eDC revealed the presence of many antihypertensive compounds. Administering the eDC in a nanoemulsion formulation (25 to 50 mg/kg) effectively normalised blood pressure in hypertensive rats. The result also suggested that neurogenic mechanisms are involved in the antihypertensive action of eDC. The treatment with p-coumaric acid (0.32 to 3 mg/kg), a polyphenol abundant in the eDC, produced no significant antihypertensive effect. The findings indicate that the eDC has antihypertensive properties, and that these effects may be mediated through neurogenic pressor mechanisms.
Keywords in Portuguese
Baccharis dracunculifolia
Propolis verde
 
Keywords
Baccharis dracunculifolia
Brazilian green propolis
P-coumaric acid
Hypertension
Salt
 
Publisher
Elsevier
Citation
BATISTA, Marcos Adriano Carlos et al. Antihypertensive effect of a nanoemulsion of baccharis dracunculifolia leaves extract in sodium-dependent hypertensive rats. Natural Product Research, 1–8. https://doi.org/10.1080/14786419.2024.2397724