| Author | Sabatke, Bruna | |
| Author | Rossi, Izadora Volpato | |
| Author | Sana, Abel | |
| Author | Bonato, Leticia Bassani | |
| Author | Ramirez, Marcel I | |
| Access date | 2024-12-12T12:18:10Z | |
| Available date | 2024-12-12T12:18:10Z | |
| Document date | 2024 | |
| Citation | SABATKE, B. et al. Extracellular vesicles biogenesis and uptake concepts: a comprehensive guide to studying host-pathogen communication. Molecular Microbiology, v. 122, n. 5, p. 613-629, 2024. | en_US |
| ISSN | 1365-2958 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67542 | |
| Sponsorship | CAPES (Funding Code 001); Conselho Nacional de Desenvolvimento Científico e Tecnológico, Grant/Award Number: 301719/2016-0, 307314/2018-9 and 404717/2016-0; FIOCRUZ and Basic Parasitology Program AUXPE 2041/2011
(CAPES) Brazil. | en_US |
| Language | eng | en_US |
| Publisher | WILEY | en_US |
| Rights | open access | en_US |
| Subject in Portuguese | Biogênese | en_US |
| Subject in Portuguese | Exossomos | en_US |
| Subject in Portuguese | Vesículas extracelulares | en_US |
| Subject in Portuguese | Microvesículas | en_US |
| Subject in Portuguese | Interação Parasita-hospedeiro | en_US |
| Title | Extracellular vesicles biogenesis and uptake concepts: a comprehensive guide to studying host–pathogen communication | en_US |
| Type | Article | en_US |
| DOI | 10.1111/mmi.15168 | |
| Abstract | The study of host–pathogen interactions has increased considerably in recent decades. This intercellular communication has been mediated by extracellular vesicles (EVs) that play an important role during the interaction. EVs are particles of lipid bilayer and described in different types of cells, eukaryotic or prokaryotic. Depending on their biogenesis they are described as exosomes (derived from multivesicular bodies) and microvesicles (derived from the plasma membrane). The EVs carry biomolecules, including nucleic acids, lipids, and proteins that can be released or internalized by other cells in different pathways (endocytosis, macropinocytosis, phagocytosis, or membrane fusion) in the process described as uptake. The balance between biogenesis and uptake of EVs could modify physiological and pathophysiological processes of the cell. This review is focusing on the dynamic roles of release and capture of EVs during host–pathogen interaction. We also do a critical analysis of methodologies for obtaining and analyzing EVs. Finally, we draw attention to critical points to be considered in EV biogenesis and uptake studies. | en_US |
| Affilliation | Federal University of Paraná. Graduate Program in Microbiology, Pathology and Parasitology. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil / Federal University of Paraná. Graduate Program in Cell and Molecular Biology. Curitiba, PR, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil / Federal University of Paraná. Graduate Program in Cell and Molecular Biology. Curitiba, PR, Brasil. | en_US |
| Affilliation | Federal University of Paraná. Graduate Program in Microbiology, Pathology and Parasitology. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil. | en_US |
| Subject | Biogenesis | en_US |
| Subject | Exosomes | en_US |
| Subject | Extracellular vesicles | en_US |
| Subject | Host–pathogen interaction | en_US |
| Subject | Microvesicles | en_US |
| Subject | Uptake | en_US |
| DeCS | Vesículas extracelulares | en_US |
| DeCS | Interações Hospedeiro-Parasita | en_US |
