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https://www.arca.fiocruz.br/handle/icict/67542
EXTRACELLULAR VESICLES BIOGENESIS AND UPTAKE CONCEPTS: A COMPREHENSIVE GUIDE TO STUDYING HOST–PATHOGEN COMMUNICATION
Exossomos
Vesículas extracelulares
Microvesículas
Interação Parasita-hospedeiro
Affilliation
Federal University of Paraná. Graduate Program in Microbiology, Pathology and Parasitology. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil / Federal University of Paraná. Graduate Program in Cell and Molecular Biology. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil / Federal University of Paraná. Graduate Program in Cell and Molecular Biology. Curitiba, PR, Brasil.
Federal University of Paraná. Graduate Program in Microbiology, Pathology and Parasitology. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil / Federal University of Paraná. Graduate Program in Cell and Molecular Biology. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil / Federal University of Paraná. Graduate Program in Cell and Molecular Biology. Curitiba, PR, Brasil.
Federal University of Paraná. Graduate Program in Microbiology, Pathology and Parasitology. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Grupo de Pesquisa em Vesículas Extracelulares e Interações Parasita-Hospedeiro. Curitiba, PR, Brasil.
Abstract
The study of host–pathogen interactions has increased considerably in recent decades. This intercellular communication has been mediated by extracellular vesicles (EVs) that play an important role during the interaction. EVs are particles of lipid bilayer and described in different types of cells, eukaryotic or prokaryotic. Depending on their biogenesis they are described as exosomes (derived from multivesicular bodies) and microvesicles (derived from the plasma membrane). The EVs carry biomolecules, including nucleic acids, lipids, and proteins that can be released or internalized by other cells in different pathways (endocytosis, macropinocytosis, phagocytosis, or membrane fusion) in the process described as uptake. The balance between biogenesis and uptake of EVs could modify physiological and pathophysiological processes of the cell. This review is focusing on the dynamic roles of release and capture of EVs during host–pathogen interaction. We also do a critical analysis of methodologies for obtaining and analyzing EVs. Finally, we draw attention to critical points to be considered in EV biogenesis and uptake studies.
Keywords in Portuguese
BiogêneseExossomos
Vesículas extracelulares
Microvesículas
Interação Parasita-hospedeiro
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