| Author | Silva, Anielly Sarana da | |
| Author | Campos, Gabriel Montenegro de | |
| Author | Altizani, Gabriela Marengone | |
| Author | Barros, Alice Chagas | |
| Author | Junqueira, Dennis Maletich | |
| Author | Kashima, Simone | |
| Author | Sampaio, Sandra Coccuzzo | |
| Author | Elias, Maria Carolina | |
| Author | Giovanetti, Marta | |
| Author | Scrideli, Carlos Alberto | |
| Author | Slavov, Svetoslav Nanev | |
| Access date | 2024-12-12T16:17:51Z | |
| Available date | 2024-12-12T16:17:51Z | |
| Document date | 2024 | |
| Citation | DA SILVA, Anielly Sarana da et al. Human pegivirus -1 (HPgV-1) RNA frequency and genotype distribution in pediatric oncology patients with febrile neutropenia. Virus Res, v. 350, p. 199479, 2024. doi.org/10.1016/j.virusres.2024.199479 | en_US |
| ISSN | 0168-1702 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/67566 | |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | restricted access | |
| Title | Human pegivirus -1 (HPgV-1) RNA frequency and genotype distribution in pediatric oncology patients with febrile neutropenia. | en_US |
| Type | Article | |
| Abstract | Human Pegivirus-1, typically regarded as a commensal virus, exhibits high prevalence in humans. Its frequency and impact on oncologic pediatric patients with febrile neutropenia (FN), a frequent chemotherapy complication, remains unexplored. In this study, we assessed HPgV-1 RNA prevalence in pediatric patients experiencing FN. Blood samples were collected from 30 children, 15 presenting FN and 15 comprising a control group of either undergoing treatment or in remission. Overall, HPgV-1 RNA was detected in 23.3 % of samples (26.7 % among FN patients and 20.0 % among those under treatment or in remission). Phylogenetic analysis unveiled HPgV-1 genotype 2 predominance among these samples, the most prevalent strain circulating in Brazil. Our findings prompt crucial inquiries into the role of HPgV-1 RNA in FN: is it an incidental finding and if it can influences this clinical entity? Further investigation is imperative to elucidate HPgV-1 implications in vulnerable patients cohorts, potentially informing new approaches and understanding viral dynamics in immunocompromised populations. | en_US |
| Affilliation | Blood Center of Ribeirão Preto. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Blood Center of Ribeirão Preto. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Department of Childcare and Pediatrics. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Central Laboratory of the General Hospital of Ribeirão Preto. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Laboratory of Bioinformatics and Virus Evolution. Department of Biochemistry and Molecular Biology. Center for Natural and Exact Sciences. Federal University of Santa Maria. Santa Maria, RS, Brazil | en_US |
| Affilliation | Blood Center of Ribeirão Preto. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Center for Viral Surveillance and Serologic Evaluation. Butantan Institute, SP, Brazil | en_US |
| Affilliation | Center for Viral Surveillance and Serologic Evaluation. Butantan Institute, SP, Brazil | en_US |
| Affilliation | Department of Science and Technology for Humans and the Environment. University of Campus Bio-Medico di Roma. Rome, Italy/Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Climate Amplified Diseases and Epidemic. Brasília, DF, Brazil | en_US |
| Affilliation | Department of Childcare and Pediatrics. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil | en_US |
| Affilliation | Center for Viral Surveillance and Serologic Evaluation. Butantan Institute, SP, Brazil | en_US |
| Subject | Febrile neutropenia | en_US |
| Subject | Human pegivirus-1 | en_US |
| Subject | Pediatric patients | en_US |
| Subject | Oncology | en_US |
| Embargo date | 3100-12-31 | |
