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3100-12-31
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HUMAN PEGIVIRUS -1 (HPGV-1) RNA FREQUENCY AND GENOTYPE DISTRIBUTION IN PEDIATRIC ONCOLOGY PATIENTS WITH FEBRILE NEUTROPENIA.
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Affilliation
Blood Center of Ribeirão Preto. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil
Blood Center of Ribeirão Preto. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil
Department of Childcare and Pediatrics. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil
Central Laboratory of the General Hospital of Ribeirão Preto. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil
Laboratory of Bioinformatics and Virus Evolution. Department of Biochemistry and Molecular Biology. Center for Natural and Exact Sciences. Federal University of Santa Maria. Santa Maria, RS, Brazil
Blood Center of Ribeirão Preto. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil
Center for Viral Surveillance and Serologic Evaluation. Butantan Institute, SP, Brazil
Center for Viral Surveillance and Serologic Evaluation. Butantan Institute, SP, Brazil
Department of Science and Technology for Humans and the Environment. University of Campus Bio-Medico di Roma. Rome, Italy/Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Climate Amplified Diseases and Epidemic. Brasília, DF, Brazil
Department of Childcare and Pediatrics. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil
Center for Viral Surveillance and Serologic Evaluation. Butantan Institute, SP, Brazil
Blood Center of Ribeirão Preto. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil
Department of Childcare and Pediatrics. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil
Central Laboratory of the General Hospital of Ribeirão Preto. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil
Laboratory of Bioinformatics and Virus Evolution. Department of Biochemistry and Molecular Biology. Center for Natural and Exact Sciences. Federal University of Santa Maria. Santa Maria, RS, Brazil
Blood Center of Ribeirão Preto. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil
Center for Viral Surveillance and Serologic Evaluation. Butantan Institute, SP, Brazil
Center for Viral Surveillance and Serologic Evaluation. Butantan Institute, SP, Brazil
Department of Science and Technology for Humans and the Environment. University of Campus Bio-Medico di Roma. Rome, Italy/Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Climate Amplified Diseases and Epidemic. Brasília, DF, Brazil
Department of Childcare and Pediatrics. Faculty of Medicine of Ribeirão Preto. University of São Paulo. Ribeirão Preto, SP, Brazil
Center for Viral Surveillance and Serologic Evaluation. Butantan Institute, SP, Brazil
Abstract
Human Pegivirus-1, typically regarded as a commensal virus, exhibits high prevalence in humans. Its frequency and impact on oncologic pediatric patients with febrile neutropenia (FN), a frequent chemotherapy complication, remains unexplored. In this study, we assessed HPgV-1 RNA prevalence in pediatric patients experiencing FN. Blood samples were collected from 30 children, 15 presenting FN and 15 comprising a control group of either undergoing treatment or in remission. Overall, HPgV-1 RNA was detected in 23.3 % of samples (26.7 % among FN patients and 20.0 % among those under treatment or in remission). Phylogenetic analysis unveiled HPgV-1 genotype 2 predominance among these samples, the most prevalent strain circulating in Brazil. Our findings prompt crucial inquiries into the role of HPgV-1 RNA in FN: is it an incidental finding and if it can influences this clinical entity? Further investigation is imperative to elucidate HPgV-1 implications in vulnerable patients cohorts, potentially informing new approaches and understanding viral dynamics in immunocompromised populations.
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