| Author | Rebolledo, Anayive Pérez | |
| Author | Ayala, José Danilo | |
| Author | Lima, Geraldo Magela de | |
| Author | Beraldo, Heloisa | |
| Author | Marchini, Nicoletta | |
| Author | Bombieri, Gabriella | |
| Author | Zani, Carlos Leomar | |
| Author | Fagundes, Elaine Maria de Souza | |
| Access date | 2013-08-08T18:15:41Z | |
| Available date | 2013-08-08T18:15:41Z | |
| Document date | 2005 | |
| Citation | PEREZ-REBOLLEDO, Anayive et al. Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes. Eur J Med Chem., v. 40, n. 5, p. 467-472, May 2005. | pt_BR |
| ISSN | 0223-5234 | |
| URI | https://www.arca.fiocruz.br/handle/icict/6772 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes. | pt_BR |
| Type | Article | |
| Abstract | Structural studies and an investigation of the cytotoxic activity of Sn(IV) complexes with N(4)-phenyl-2-benzoylpyridine thiosemicarbazone (H2Bz4Ph) were carried out. The crystal and molecular structures of [Sn(2Bz4Ph)Cl3].CH3CH2OH (1) and [Sn(2Bz4Ph)BuCl2].H2O (Bu = butyl group) (2) were determined. Both compounds present octahedral coordination geometry with the 2Bz4Ph anionic ligand behaving as tridentate on the metal ion. A comparative study of the structures of these compounds along with that of [Sn(2Bz4Ph)Bu2Cl] (3) determined before is presented. The cytotoxicity of H2Bz4Ph and its Sn(IV) complexes was investigated against the MCF-7, TK-10 and UACC-62 human tumor cell lines. Among the three complexes, 3 proved to be better as cytotoxic agent than the clinically used drug etoposide. H2Bz4Ph and all complexes were able to induce apoptosis in UACC-62 cells. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Departamento de Química. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Università di Milano. Istituto di Chimica Farmaceutica e Tossicologica. Milano, Italy. | pt_BR |
| Affilliation | Università di Milano. Istituto di Chimica Farmaceutica e Tossicologica. Milano, Italy. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
| DeCS | Thiosemicarbazones | pt_BR |
| DeCS | Tin(IV) complexes | pt_BR |
| DeCS | Crystal structures | pt_BR |
| DeCS | Cytotoxic activity | pt_BR |
