| Author | Soares, Taciana de Figueiredo | |
| Author | Rocha, Gifone Aguiar | |
| Author | Rocha, Andreia Maria Camargos | |
| Author | Oliveira, Celso Afonso de | |
| Author | Queiroz, Dulciene Maria de Magalhães | |
| Author | Oliveira, Rodrigo Correa de | |
| Author | Martins Filho, Olindo Assis | |
| Author | Carvalho, Anfrisina Sales Teles de | |
| Author | Bittencourt, Paulo Fernando Souto | |
| Author | Faria, Ana Maria Caetano de | |
| Access date | 2013-08-20T15:38:23Z | |
| Available date | 2013-08-20T15:38:23Z | |
| Document date | 2005 | |
| Citation | SOARES, Taciana de Figueiredo et al. Phenotypic study of peripheral blood lymphocytes and humoral immune response in Helicobacter pylori infection according to age. Scand J Immunol., v. 62, n. 1, p. 63-70, July 2005. | pt_BR |
| ISSN | 0300-9475 | |
| URI | https://www.arca.fiocruz.br/handle/icict/6805 | |
| Language | eng | pt_BR |
| Publisher | Blackwell Publishing | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Phenotypic study of peripheral blood lymphocytes and humoral immune response in Helicobacter pylori infection according to age | pt_BR |
| Type | Article | |
| DOI | 10.1111/j.1365-3083.2005.01638.x | |
| Abstract | There are differences between children and adults in certain aspects of the Helicobacter pylori (HP) infection, among them the lower titre of IgG antibodies anti-HP in the former group. Thus, we investigated by means of flow cytometry CD4+/CD3+ (CD4+T), CD8+/CD3+ (CD8+T) and CD19+/CD3- (B) cells, activation/co-stimulatory markers (CD4+/HLA-DR+, CD4+/CD28+, CD8+/HLA-DR+ and CD8+/CD28+) and by means of ELISA IgG anti-HP antibodies in the peripheral blood from HP-positive and -negative children and adults. An increased CD4+/CD28+ and CD8+/CD28+ percentage and number of CD4+/CD3+ cells were seen in infected adults. Conversely, no difference was observed between infected and noninfected children, but when they were stratified by age, an increased CD4+/CD28+ cell percentage was seen in the HP-positive group older than 10 years. The mean level of IgG anti-HP was lower in younger infected children, increased with age and correlated with CD4+ cells. Our data suggest that the immune response to HP infection vary according to the age. Low percentage of activated CD4+ cell may contribute to the lower level of serum IgG anti-HP observed in younger infected children. In addition, the CD4+ cell participation during the infection seems to begin after 10 years old, when the immune response becomes similar to that seen in adults. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Laboratory of Research in Bacteriology. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Laboratory of Research in Bacteriology. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Laboratory of Research in Bacteriology. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Laboratory of Research in Bacteriology. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Laboratory of Research in Bacteriology. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Research Center Rene Rachou. Laboratory of Cellular and Molecular Immunology. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Research Center Rene Rachou. Laboratory of Chagas’ Diseases. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Department of Pediatrics. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Hospital Felicio Rocho. Service of Endoscopy. Belo Horizonte, MG, Brazil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Department of Biochemistry and Immunology. Belo Horizonte, MG, Brazil. | pt_BR |
| Subject | Antibodies, Bacterial/blood | pt_BR |
| Subject | Antigens, CD/analysis | pt_BR |
| Subject | B-Lymphocytes/classification | pt_BR |
| Subject | Helicobacter infections/immunology | pt_BR |
| Subject | Helicobacter pylori | pt_BR |
| Subject | Immunoglobulin G/blood | pt_BR |
