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INDIVIDUAL PATIENT DATA META-ANALYSIS ESTIMATES THE MINIMAL DETECTABLE CHANGE OF THE GERIATRIC DEPRESSION SCALE-15.
Gonzalez-Domınguez, Nadia P. et al. | Date Issued: 2024
Author
Gonzalez-Domınguez, Nadia P.
Wu, Yin
Fan, Suiqiong
Levis, Brooke
Sun, Ying
Gilbody, Simon
Ioannidis, John P.A.
Harel, Daphna
Vigod, Simone N.
Markham, Sarah
Ziegelstein, Roy C.
Cuijpers, Pim
Patten, Scott B.
Boruff, Jill T.
Thombs, Brett D.
Benedetti, Andrea
Costa, Maria Fernanda Furtado Lima
The DEPRESsion Screening Data (DEPRESSD) GDS Author Group2
Affilliation
Department of Epidemiology, Biostatistics, and Occupational Health. McGill University. Montreal, Quebec, Canada. / Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada.
Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada.
Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada.
Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada.
Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada.
Hull York Medical School and the Department of Health Sciences. University of York. Heslington, York, UK.
Department of Medicine. Department of Epidemiology and Population Health. Department of Biomedical Data Science. Department of Statistics. Stanford University. Stanford, CA, USA.
Department of Applied Statistics, Social Science, and Humanities. New York University. New York, NY, USA.
Women’s College Hospital and Research Institute. University of Toronto. Toronto, Ontario, Canada.
Department of Biostatistics and Health Informatics. King’s College London. London, UK.
Department of Medicine. Johns Hopkins University School of Medicine. Baltimore, Maryland, USA.
Department of Clinical. Neuro and Developmental Psychology. Amsterdam Public Health Research Institute. Vrije Universiteit. Amsterdam, The Netherlands.
Department of Community Health Sciences. University of Calgary. Calgary, Alberta, Canada.
Schulich Library of Physical Sciences, Life Sciences, and Engineering. McGill University. Montreal, Quebec, Canada.
Department of Epidemiology, Biostatistics, and Occupational Health. McGill University. Montreal, Quebec, Canada. / Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada. / Department of Psychiatry. McGill University. Montreal, Quebec, Canada. / Department of Medicine. McGill University. Montreal, Quebec, Canada. / Department of Psychology. McGill University. Montreal, Quebec, Canada. / Biomedical Ethics Unit. McGill University. Montreal, Quebec, Canada.
Department of Epidemiology, Biostatistics, and Occupational Health. McGill University. Montreal, Quebec, Canada. / Department of Medicine. McGill University. Montreal, Quebec, Canada. / Respiratory Epidemiology and Clinical Research Unit. McGill University Health Centre. Montreal, Quebec, Canada.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil. por The DEPRESsion Screening Data (DEPRESSD)
Autores com diversas filiações em notas
Abstract
Objectives: To use individual participant data meta-analysis (IPDMA) to estimate the minimal detectable change (MDC) of the Geriatric Depression Scale-15 (GDS-15) and to examine whether MDC may differ based on participant characteristics and study-level variables. Study Design and Setting: This was a secondary analysis of data from an IPDMA on the depression screening accuracy of the GDS. Datasets from studies published in any language were eligible for the present study if they included GDS-15 scores for participants aged 60 or older. MDC of the GDS-15 was estimated via random-effects meta-analysis using 2.77 (MDC95) and 1.41 (MDC67) standard errors of measurement. Subgroup analyses were used to evaluate differences in MDC by participant age and sex. Meta-regression was conducted to assess for differences based on study-level variables, including mean age, proportion male, proportion with major depression, and recruitment setting. Results: 5876 participants (mean age 76 years, 40% male, 11% with major depression) from 21 studies were included. The MDC95 was 3.81 points (95% confidence interval [CI] 3.59, 4.04), and MDC67 was 1.95 (95% CI 1.83, 2.03). The difference in MDC95 was 0.26 points (95% CI 0.04, 0.48) between ≥80-year-olds and <80-year-olds; MDC95 was similar for females and males (0.05, 95% CI −0.12, 0.22). The MDC95 increased by 0.29 points (95% CI 0.17, 0.41) per 10% increase in proportion of participants with major depression; mean age had a small association (0.04 points, 95% CI 0.00 to 0.09) with MDC95, but sex and recruitment setting were not significantly associated. Conclusion: The MDC95 was 3.81 points and MDC67 was 1.95 points. MDC95 increased with the proportion of participants with major depression. Results can be used to evaluate individual changes in depression symptoms and as a threshold for assessing minimal clinical important difference estimates.
Keywords
Minimal detectable change
GDS-15
Individual participant data meta-analysis
Minimally important difference
Standard error of measurement
Depression
Depression symptoms
 
Publisher
Elsevier
Citation
GONZÁLEZ-DOMÍNGUEZ, Nadia P. et al. Individual patient data meta-analysis estimates the minimal detectable change of the Geriatric Depression Scale-15. Journal Of Clinical Epidemiology, v. 173, p. 1-10, 2024.
DOI
10.1016/j.jclinepi.2024.111443
ISSN
0895-4356
Notes
DEPRESSD GDS Author Group: Ankur Krishnan Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada. Chen He, Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada. Tiffany Dal Santo, Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada. Dipika Neupane, Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada. Eliana Brehaut Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada. Parash M. Bhandari Lady Davis Institute for Medical Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada. Xia Qiu, Department of Pediatrics. West China Second University Hospital. Sichuan University, Chengdu, China Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada. Mahrukh Imran, Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada. Elsa-Lynn Nassar, Lady Davis Institute for Medical Research. Jewish General Hospital. Montreal, Quebec, Canada. Kathryn Betts Adams Independent Researcher/Consultant, West Hartford, Connecticut. Antje-Kathrin Allgaier, Institute of Psychology. Universit€at der Bundeswehr M€unchen. Neubiberg, Germany; Sarah F. Baillon, Leicestershire Partnership NHS Trust. Leicester, UK Paulo Caramelli, Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Interna. Belo Horizonte, MG, Brasil. Erico Castro-Costa Centro de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil. Marcos H.N. Chagas Universidade de São Paulo. Departamento de Neurociências e Comportamento. Ribeirão Preto, SP, Brasil. Sarah Cullum, The University of Auckland. Auckland, New Zealand. Filipi L.C. Dias, Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil. Ahmet Turan Isik, Unit for Aging Brain and Dementia. Department of Geriatric Medicine. Faculty of Medicine. Dokuz Eylul University. Izmir, Turkey. Nathalie Jett_ Department of Clinical Neurosciences. University of Calgary, Calgary. Alberta, Canada. Patricia Katz Department of Medicine. University of California San Francisco. San Francisco, CA, USA. Wonhyoung Kim Department of psychiatry. Inha University Hospital. Incheon, Republic of Korea. Hans-Helmut K€onig Department of Health Economics and Health Services Research. University Medical Center Hamburg-Eppendorf, Germany. Maria Fernanda Furtada Lima Costa Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil Margrit L€obner, Institute of Social Medicine. Occupational Health and Public Health. University of Leipzig. Leipzig, Germany. Seyed Kazem Malakouti School of Behavioral Sciences and Mental Health. Mental Health Geriatric Research Center. Iran University of Medical Sciences. Tehran, Iran Laura Marsh Department of Psychiatry & Behavioral Sciences. Baylor College of Medicine. Houston, Texas, USA. Heehyul E. Moon Kent School of Social Work & Family Science. University of Louisville. Kentucky, USA. Antonis A. Mougias Nestor Psychogeriatric Association. Athens, Greece. Christian J Nelson Department of Psychiatry and Behavioral Sciences. Memorial Sloan Kettering Cancer Center. New York, USA Alexander Pabst Institute of Social Medicine. Occupational Health and Public Health. Medical Faculty. University of Leipzig, Leipzig, Germany. Terence J. Quinn Institute of Cardiovascular and Medical Sciences. University of Glasgow. Glasgow, UK. Steffi G. Riedel-Heller, Institute of Social Medicine. Occupational Health and Public Health. Medical Faculty. University of Leipzig. Leipzig, Germany Rebecca Saracino Department of Psychiatry and Behavioral Sciences. Memorial Sloan Kettering Cancer Center. New York, USA Martin Scherer. Institute of Primary Medical Care. University Medical Center Hamburg-Eppendorf. Hamburg, Germany. Matthias Volz Department of Psychology. University of Kassel. Germany. Michael Wagner Department of Geriatric PSychiatry and Neurodegenerative Diseases. University Hospital Bonn. Bonn, Germany. Siegfried B. Weyerer Central Institute of Mental Health. Medical Faculty Mannheim/Heidelberg University. Mannheim, Germany.