| Author | Rangel, Caroline Lacorte | |
| Author | Fontes, Silvia da Silva | |
| Author | Silva, Marcus Vinicius de Mattos | |
| Author | Jesus, Jorlan Fernandes de | |
| Author | Mansur, Janaina Figueira | |
| Author | Silva, Emmanuel Messias Vilar Gonçalves da | |
| Author | Costa Neto, Sócrates Fraga da | |
| Author | Novaes, Roberto Leonan Morim | |
| Author | Pinto, Pedro Cordeiro Estrela de Andrade | |
| Author | Rocha, Ricardo Moratelli Mendonça da | |
| Author | Lemos, Elba Regina Sampaio de | |
| Author | Borges, Ronaldo da Silva Mohana | |
| Author | Silva, Rodrigo Nunes Rodrigues da | |
| Author | Santos, Renata Carvalho de Oliveira Pires dos | |
| Access date | 2025-01-15T20:22:17Z | |
| Available date | 2025-01-15T20:22:17Z | |
| Document date | 2024 | |
| Citation | RANGEL, Caroline Lacorte et al. Serological evidence of hantavirus in bats from the brazilian Atlantic Forest: an investigation of seroreactivity and cross-reactivity of neotropical bat samples using nucleoproteins of rodent- and bat-borne hantaviruses. Viruses, v. 16, n. 12, p. 1-14, 29 Nov. 2024. | |
| ISSN | 1999-4915 | |
| URI | https://www.arca.fiocruz.br/handle/icict/68097 | |
| Description | Produção científica do Laboratório de Hantaviroses e Rickettsioses. | pt_BR |
| Sponsorship | The budget and infrastructure needed to carry out this project were provided by the Hantavirus and Rickettsiosis Laboratory (LHR) of the Oswaldo Cruz Institute/Fiocruz, which has a laboratory structure for storing and handling animal samples, as well as the consumables and supplies needed to carry out the serological protocols and techniques. The project also has the expertise and infrastructure of the Structural Genomics Laboratory (Biophysics/UFRJ). Related projects and funding agencies: This research was funded by the National Council for Scientific and Technological Development (CNPq): Rede BioM.A–process number: 457524/2012-0); the Carlos Chagas Filho Foundation for Research Support in the State of Rio de Janeiro (FAPERJ): APQ1-process number E_27/211.553/2021, JPF-process number E26/200.631/2022, and CNE-process numbers E-26/200.967/2021 and E-26/210.071/2023. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior–Brasil (CAPES)–Finance Code 001. | |
| Language | eng | en_US |
| Publisher | MDPI | |
| Rights | open access | |
| Title | Serological evidence of hantavirus in bats from the brazilian Atlantic Forest: an investigation of seroreactivity and cross-reactivity of neotropical bat samples using nucleoproteins of rodent- and bat-borne hantaviruses | en_US |
| Type | Article | |
| DOI | 10.3390/v16121857 | |
| Abstract | Hantaviruses are zoonotic pathogens associated with severe human diseases such as hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Despite the extensive study of rodent-borne hantaviruses, research on bat-associated hantaviruses remains limited. This study aimed to investigate the seroprevalence and cross-reactivity of neotropical bat samples with rodent- and bat-associated recombinant hantavirus nucleoproteins (rNPs) to improve hantavirus surveillance in the Brazilian Atlantic Forest. The studied bat population consisted of 336 blood samples collected over nearly a decade in five Brazilian states (Bahia, Rio de Janeiro, Santa Catarina, Paraná, and Minas Gerais). Antibodies were detected using IgG ELISA assays with rNPs from bat-borne Mobatvirus xuansonense (XSV) and Loanvirus brunaense (BRNV) and the rodent-borne hantaviruses Orthohantavirus andesense (ANDV) and Orthohantavirus seoulense (SEOV). Results indicated a higher seroprevalence for the BRNV rNP (36.6%) compared to ANDV (7.4%), SEOV (5.7%), and XSV (0.6%). The high sensitivity of the BRNV rNP and the cross-reactivity observed with the ANDV rNP, the main protein used for serological tests in the Americas, indicates that BRNV rNP is a better antigen for the accurate detection of antibodies against hantaviruses in Brazilian bats. These findings underscore the presence of unknown hantaviruses antigenically similar to BRNV in Brazilian bat populations and highlight the urgent need for identifying better antigens for comprehensive hantavirus monitoring in bats. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Genômica Estrutural. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Centro Biomédico. Faculdade de Ciências Biológicas e Saúde. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Genômica Estrutural. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal da Paraíba. Centro de Ciências Exatas e da Natureza. Departamento de Sistemática e Ecologia. Laboratório de Mamíferos. João Pessoa, PB, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Mata Atlântica. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Mata Atlântica. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal da Paraíba. Centro de Ciências Exatas e da Natureza. Departamento de Sistemática e Ecologia. Laboratório de Mamíferos. João Pessoa, PB, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Fiocruz Mata Atlântica. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Genômica Estrutural. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses. Rio de Janeiro, RJ, Brasil. | |
| Subject | Bat-borne virus | en_US |
| Subject | Seroprevalence | en_US |
| Subject | Chiroptera | en_US |
| Subject | Tropical rainforest | en_US |
| Subject | Recombinant nucleoproteins | en_US |
| Subject | ELISA | en_US |
| e-ISSN | 1999-4915 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 09 Indústria, inovação e infraestrutura | |
| xmlui.metadata.dc.subject.ods | 15 Vida terrestre | |
