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IL-17A/IFN-γ PRODUCING γδ T CELL FUNCTIONAL DICHOTOMY IMPACTS CUTANEOUS LEISHMANIASIS IN MICE
https://www.arca.fiocruz.br/handle/icict/62741
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Abstract
γδ T cells play diverse roles in immune responses, producing either interleukin (IL)-17A or interferon γ (IFN-γ). Here, we investigated the impact of this functional dichotomy on cutaneous leishmaniasis. We demonstrate that in Sv129 mice susceptible to Leishmania amazonensis, Vγ4⁺ γδ T cells are the main source of IL-17A. In type 1 IFN receptor–deficient (A129) mice with heightened susceptibility, there is an increased frequency of IL-17A–producing γδ T cells. L. amazonensis' lipophosphoglycan induces these IL-17A–producing γδ T cells. Notably, C57BL/6 mice deficient in γδ T cells or IL-17 receptor exhibit smaller lesions, indicating a pathogenic role of IL-17A–producing γδ T cells in cutaneous leishmaniasis. Conversely, adoptive transfer of fluorescence-activated cell sorting (FACS)–sorted γδ T cells lead to an accumulation of IFN-γ–producing γδ T cells, associated with control of lesion development. On the other hand, adoptive transfer of FACS–sorted IFN-γ–deficient γδ T cells abolished the control of lesion development. These data demonstrate a pathophysiological dichotomy in which IL-17A–producing γδ T cells promote pathogenesis, while IFN-γ–producing γδ T cells offer therapeutic potential in cutaneous leishmaniasis.
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