| Author | Terzian, Ana Carolina Bernardes | |
| Author | Azar, Sasha R | |
| Author | Estofolete, Cassia F | |
| Author | Nogueira, Mauricio L | |
| Author | Vasilakis, Nikos | |
| Access date | 2025-02-03T18:04:57Z | |
| Available date | 2025-02-03T18:04:57Z | |
| Document date | 2024 | |
| Citation | TERZIAN, Ana Carolina Bernardes et al. Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine Strains. Vaccines, v. 12, n. 12, 1311, 2024. | en_US |
| ISSN | 2076-393X | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68387 | |
| Language | eng | en_US |
| Publisher | MDPI AG | en_US |
| Rights | open access | en_US |
| Title | Differential Neutralization Profiles of 17DD Vaccinated Population to 17D-204 and 17DD Vaccine Strains. | en_US |
| Type | Article | en_US |
| DOI | 10.3390/vaccines12121311 | |
| Abstract | Background/Objectives: Yellow fever virus (YFV) (Flaviviridae, Orthoflavivirus) is the etiologic agent of yellow fever (YF), a vector-borne disease with significant morbidity and mortality across the tropics and neotropics, despite having a highly efficacious and safe vaccine (17D). Vaccination provides lifelong protection from YF disease mediated by humoral immunity. There are several versions of the original 17D vaccine: 17D-204 (marketed in the USA as YF-VAX, in France as Stamaril, and in China as Tiantan-V), 17D-213 (Russian Federation), and 17DD (by FIOCRUZ in Brazil). Vaccines produced in the US, France, Senegal, China, and Russia represent 17D-204-derived strains, whereas the Brazilian 17DD has a unique passage/attenuation history from 17D-204-derived strains. Their functional differences in the neutralization profiles are not known. Methods: The Plaque Reduction Neutralization Test (PRNT) was used to determine the neutralization profiles of sera from 209 patients that were previously vaccinated with the 17DD strain against both 17D-204 and 17DD. Results: Sera exhibited significantly more efficient neutralization of 17DD (mean reciprocal PRNT50 183, PRNT80 86, median reciprocal PRNT50 80, and PRNT80 40) compared to 17D-204 (mean reciprocal PRNT50 91, PRNT80 33, median reciprocal PRNT50 40, and PRNT80 10). Conclusions: Our data indicate antigenic differences between 17D and 17DD vaccines. | en_US |
| Affilliation | Fundação Osvaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil. | en_US |
| Affilliation | Center for Tissue Engineering. Department of Surgery. Houston Methodist Research Institute. Houston Methodist Hospital. Houston, TX, USA. / Department of Pathology. University of Texas Medical Branch, Galveston, TX, USA. | en_US |
| Affilliation | Faculdade de Medicina de São José do Rio Preto. Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias. Laboratório de Pesquisas em Virologia. São José do Rio Preto, SP, Brasil. / Fundação Faculdade Regional de Medicina de São José do Rio Preto. Hospital de Base. São José do Rio Preto, SP, Brasil. | en_US |
| Affilliation | Faculdade de Medicina de São José do Rio Preto. Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias. Laboratório de Pesquisas em Virologia. São José do Rio Preto, SP, Brasil. / Fundação Faculdade Regional de Medicina de São José do Rio Preto. Hospital de Base. São José do Rio Preto, SP, Brasil. | en_US |
| Affilliation | Department of Pathology. University of Texas Medical Branch. Galveston, TX, USA. / Center for Vector-Borne and Zoonotic Diseases. University of Texas Medical Branch. Galveston, TX, USA. / Institute for Human Infection and Immunity. University of Texas Medical Branch. Galveston, TX, USA. | en_US |
| Subject | YFV | en_US |
| Subject | Immune response | en_US |
| Subject | Neutralizing antibodies | en_US |
| Subject | Vaccine | en_US |
