Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/68387
DIFFERENTIAL NEUTRALIZATION PROFILES OF 17DD VACCINATED POPULATION TO 17D-204 AND 17DD VACCINE STRAINS.
Author
Affilliation
Fundação Osvaldo Cruz. Instituto René Rachou. Laboratório de Imunologia Celular e Molecular. Belo Horizonte, MG, Brasil.
Center for Tissue Engineering. Department of Surgery. Houston Methodist Research Institute. Houston Methodist Hospital. Houston, TX, USA. / Department of Pathology. University of Texas Medical Branch, Galveston, TX, USA.
Faculdade de Medicina de São José do Rio Preto. Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias. Laboratório de Pesquisas em Virologia. São José do Rio Preto, SP, Brasil. / Fundação Faculdade Regional de Medicina de São José do Rio Preto. Hospital de Base. São José do Rio Preto, SP, Brasil.
Faculdade de Medicina de São José do Rio Preto. Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias. Laboratório de Pesquisas em Virologia. São José do Rio Preto, SP, Brasil. / Fundação Faculdade Regional de Medicina de São José do Rio Preto. Hospital de Base. São José do Rio Preto, SP, Brasil.
Department of Pathology. University of Texas Medical Branch. Galveston, TX, USA. / Center for Vector-Borne and Zoonotic Diseases. University of Texas Medical Branch. Galveston, TX, USA. / Institute for Human Infection and Immunity. University of Texas Medical Branch. Galveston, TX, USA.
Center for Tissue Engineering. Department of Surgery. Houston Methodist Research Institute. Houston Methodist Hospital. Houston, TX, USA. / Department of Pathology. University of Texas Medical Branch, Galveston, TX, USA.
Faculdade de Medicina de São José do Rio Preto. Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias. Laboratório de Pesquisas em Virologia. São José do Rio Preto, SP, Brasil. / Fundação Faculdade Regional de Medicina de São José do Rio Preto. Hospital de Base. São José do Rio Preto, SP, Brasil.
Faculdade de Medicina de São José do Rio Preto. Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias. Laboratório de Pesquisas em Virologia. São José do Rio Preto, SP, Brasil. / Fundação Faculdade Regional de Medicina de São José do Rio Preto. Hospital de Base. São José do Rio Preto, SP, Brasil.
Department of Pathology. University of Texas Medical Branch. Galveston, TX, USA. / Center for Vector-Borne and Zoonotic Diseases. University of Texas Medical Branch. Galveston, TX, USA. / Institute for Human Infection and Immunity. University of Texas Medical Branch. Galveston, TX, USA.
Abstract
Background/Objectives: Yellow fever virus (YFV) (Flaviviridae, Orthoflavivirus) is the etiologic agent of yellow fever (YF), a vector-borne disease with significant morbidity and mortality across the tropics and neotropics, despite having a highly efficacious and safe vaccine (17D). Vaccination provides lifelong protection from YF disease mediated by humoral immunity. There are several versions of the original 17D vaccine: 17D-204 (marketed in the USA as YF-VAX, in France as Stamaril, and in China as Tiantan-V), 17D-213 (Russian Federation), and 17DD (by FIOCRUZ in Brazil). Vaccines produced in the US, France, Senegal, China, and Russia represent 17D-204-derived strains, whereas the Brazilian 17DD has a unique passage/attenuation history from 17D-204-derived strains. Their functional differences in the neutralization profiles are not known. Methods: The Plaque Reduction Neutralization Test (PRNT) was used to determine the neutralization profiles of sera from 209 patients that were previously vaccinated with the 17DD strain against both 17D-204 and 17DD. Results: Sera exhibited significantly more efficient neutralization of 17DD (mean reciprocal PRNT50 183, PRNT80 86, median reciprocal PRNT50 80, and PRNT80 40) compared to 17D-204 (mean reciprocal PRNT50 91, PRNT80 33, median reciprocal PRNT50 40, and PRNT80 10). Conclusions: Our data indicate antigenic differences between 17D and 17DD vaccines.
Share