| Author | Souza, Alex Sandro Rolland | |
| Author | Cordeiro, Marli Tenorio | |
| Author | Meneses, Jucile do Amaral | |
| Author | Honorato, Emanuele | |
| Author | Araujo Júnior, Edward | |
| Author | Castanha, Priscila Mayrelle da Silva | |
| Author | Caiado, Bruna Varginha Ramos | |
| Author | Faquini, Silvia de Lourdes Loreto | |
| Author | Santos Neto, Orlando Gomes | |
| Author | Schettini, Juliana Araújo de Carvalho | |
| Author | Mello, Luisa Medeiros de | |
| Author | Ishigami, Ana Catarina | |
| Author | Dhalia, Rafael | |
| Access date | 2025-02-06T13:46:13Z | |
| Available date | 2025-02-06T13:46:13Z | |
| Document date | 2016 | |
| Citation | SOUZA, A. S. R. et al.. Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report. Revista Brasileira de Saúde Materno Infantil, v. 16, n. 4, p. 467–473, out. 2016. | en_US |
| ISSN | 1806-9804 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68446 | |
| Language | eng | en_US |
| Publisher | Instituto de Medicina Integral Prof. Fernando Figueira | en_US |
| Rights | open access | en_US |
| Title | Clinical and laboratory diagnosis of congenital Zika virus syndrome and diaphragmatic unilateral palsy: case report | en_US |
| Alternative title | Diagnostico clínico e laboratorial do Zika vírus congênito e paralisia
diafragmática unilateral: o relato de um caso | pt_BR |
| Type | Article | en_US |
| DOI | 10.1590/1806-93042016000400007 | |
| Abstract | Introduction: several birth defects associated to congenital Zika virus infection have been reported, although the clinical features have not been fully characterized. Description: this is the first case report on unilateral diaphragmatic paralysis diagnosed on a neonate with congenital Zika confirmed by the examination of the amniotic fluid through polymerase chain reaction (ZIKV RT-PCR) and the examination of cerebrospinal fluid by serological test (IgM ZIKV-ELISA) after birth. The main manifestations detected by intrauterine ultrasound were: microcephaly, ventriculomegaly, intracranial calcifications, enlarged cisterna magna, increased amniotic fluid index and fetal akinesia syndrome. The
newborn had acute respiratory failure in the first hours of life, requiring mechanical ventila tion. The X- ray of the chest showed unilateral diaphragmatic paralysis and cardiomegaly. Discussion: diaphragmatic palsy in congenital Zika has not been previously reported, the etiopathogenic mechanisms of this event in congenital Zika virus needs to be elucidated. | en_US |
| Affilliation | Instituto de Medicina Integral Professor Fernando Figueira. Centro aos cuidados da mulher. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil. | en_US |
| Affilliation | Instituto de Medicina Integral Professor Fernando Figueira. Departamento de Neonatologia. Recife, PE, Brasil. | en_US |
| Affilliation | Instituto de Medicina Integral Professor Fernando Figueira. Centro aos cuidados da mulher. Recife, PE, Brasil. | en_US |
| Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Obstetrícia. São Paulo, SP, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil. | en_US |
| Affilliation | Instituto de Medicina Integral Professor Fernando Figueira. Centro aos cuidados da mulher. Recife, PE, Brasil. | en_US |
| Affilliation | Instituto de Medicina Integral Professor Fernando Figueira. Centro aos cuidados da mulher. Recife, PE, Brasil. | en_US |
| Affilliation | Instituto de Medicina Integral Professor Fernando Figueira. Laboratório de Pesquisa Translacional. Recife, PE, Brasil. | en_US |
| Affilliation | Instituto de Medicina Integral Professor Fernando Figueira. Departamento de Neonatologia. Recife, PE, Brasil. | en_US |
| Affilliation | Instituto de Medicina Integral Professor Fernando Figueira. Departamento de Neonatologia. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Aggeu Magalhães. Departamento de Virologia. Recife, PE, Brasil. | en_US |
| Subject | Microcephaly | en_US |
| Subject | Arbovirus infections | en_US |
| Subject | Arthrogryposis | en_US |
| Subject | Prenatal ultrasound | en_US |
| Subject | Respiratory paralysis | en_US |
