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CLINICAL AND LABORATORY DIAGNOSIS OF CONGENITAL ZIKA VIRUS SYNDROME AND DIAPHRAGMATIC UNILATERAL PALSY: CASE REPORT
Alternative title
Diagnostico clínico e laboratorial do Zika vírus congênito e paralisia diafragmática unilateral: o relato de um casoAuthor
Affilliation
Abstract
Introduction: several birth defects associated to congenital Zika virus infection have been reported, although the clinical features have not been fully characterized. Description: this is the first case report on unilateral diaphragmatic paralysis diagnosed on a neonate with congenital Zika confirmed by the examination of the amniotic fluid through polymerase chain reaction (ZIKV RT-PCR) and the examination of cerebrospinal fluid by serological test (IgM ZIKV-ELISA) after birth. The main manifestations detected by intrauterine ultrasound were: microcephaly, ventriculomegaly, intracranial calcifications, enlarged cisterna magna, increased amniotic fluid index and fetal akinesia syndrome. The
newborn had acute respiratory failure in the first hours of life, requiring mechanical ventila tion. The X- ray of the chest showed unilateral diaphragmatic paralysis and cardiomegaly. Discussion: diaphragmatic palsy in congenital Zika has not been previously reported, the etiopathogenic mechanisms of this event in congenital Zika virus needs to be elucidated.
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