Large outbreaks of dengue, Zika, and chikungunya are taking place in several countries in Asia and Latin America [1,2], and simultaneous circulation of these 3 arboviruses in the same region raises the possibility of coinfections of vertebrate and invertebrate hosts. Indeed, several cases of dengue and chikungunya coinfections have been reported [3]. However, cocirculation of Zika and chikungunya is more recent. The 2013 outbreak in the French Polynesia [4] and the 2015 outbreak in Brazil [5] are the largest Zika virus outbreaks described to date. In Brazil, the Zika and chikungunya outbreaks partially overlapped, and few reports of coinfection are present in the literature [6,7]. Here, we report a severe case of meningoencephalitis associated with peripheral polyneuropathy in a 74-year-old patient due to a coinfection with Zika and chikungunya.