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CARDIAC REMODELING AND INFLAMMATION DETECTED BY MAGNETIC RESONANCE IMAGING IN COVID-19 SURVIVORS
Schaustz, Eduardo B. et al. | Date Issued: 2024
Author
Schaustz, Eduardo B.
Secco, José Carlos P.
Barroso, Julia M.
Ferreira, Juliana R.
Tortelly, Mariana B.
Pimentel, Adriana L.
Figueiredo, Ana Cristina B. S.
Albuquerque, Denilson C.
Sales, Allan R. Kluser
Rosado de-Castro, Paulo H.
Pinheiro, Martha V. T.
Souza, Olga F.
Medei, Emiliano
Luiz, Ronir R.
Sousa, Andrea Silvestre
Camargo, Gabriel C.
Moll-Bernardes, Renata
Affilliation
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D’Or São Luiz. Cardiology and Internal Medicine Department. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D’Or São Luiz. Cardiology and Internal Medicine Department. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D’Or São Luiz. Cardiology and Internal Medicine Department. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D’Or São Luiz. Cardiology and Internal Medicine Department. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rio de Janeiro State University. Cardiology Department. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Coração. São Paulo, SP, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Rede D’Or São Luiz. Cardiology and Internal Medicine Department. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. National Center for Structural Biology and Bioimaging. Rio de Janeiro, RJ, Brazil
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute for Studies in Public Health. Rio de Janeiro, RJ, Brazil
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Chagas Disease Clinical Research Laboratory. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
Abstract
Background: Concerns have been raised about cardiac inflammation in patients with long COVID-19, particularly those with myocardial injury during the acute phase of the disease. This study was conducted to examine myopericardial involvement, detected by cardiac magnetic resonance (CMR) imaging in patients hospitalized for COVID-19. Methods: Adult patients hospitalized with COVID-19 who presented myocardial injury or increased D-dimers were enrolled in this prospective study. All patients were invited to undergo CMR imaging examination after discharge. During follow-up, patients with nonischemic myocardial or pericardial involvement detected on the first CMR imaging examination underwent second examinations. CMR imaging findings were compared with those of a control group of healthy patients with no comorbidity. Results: Of 180 included patients, 53 underwent CMR imaging examination. The mean age was 58.4 ± 18.3 years, and 73.6 % were male. Myocardial and pericardial LGE was reported in 43.4 % and 35.8 % of patients, respectively. Nonischemic myocardial or pericardial involvement was reported in 26 (49.1 %) patients. The prevalence of pericardial LGE was associated inversely with the interval between hospital discharge and CMR. COVID-19 survivors had higher end-systolic volume indices (ESVis) and lower left-ventricular ejection fractions than did healthy controls. Seventeen patients underwent follow-up CMR imaging; the end-diastolic volume index, ESVi, and prevalence of pericardial LGE, but not that of nonischemic LGE, were reduced. Conclusion: Among COVID-19 survivors with myocardial injury during the acute phase of the disease, the incidences of nonischemic myocardial and pericardial LGE and CMR imaging-detected signs of cardiac remodeling, partially reversed during follow-up, were high.
Keywords
Myocardial edema
T2
Extracellular volume
Late gadolinium enhancement
Native T1
Long COVID-19
 
Publisher
Elsevier
Citation
SCHAUSTZ, Eduardo B. et al. Cardiac remodeling and inflammation detected by magnetic resonance imaging in COVID-19 survivors. International Journal of Cardiology Heart & Vasculature, v. 54, p. 1-7, Aug. 2024.
DOI
10.1016/j.ijcha.2024.101499
ISSN
2352-9067