| Author | Ferreira, Maria Lucia Brito | |
| Author | Brito, Carlos Alexandre Antunes de | |
| Author | Moreira, Álvaro José Porto | |
| Author | Machado, Maria Íris de Morais | |
| Author | Henriques-Souza, Adélia | |
| Author | Cordeiro, Marli Tenório | |
| Author | Marques Jr., Ernesto Torres de Azevedo | |
| Author | Pena, Lindomar José | |
| Access date | 2025-02-12T16:45:51Z | |
| Available date | 2025-02-12T16:45:51Z | |
| Document date | 2017 | |
| Citation | FERREIRA, Maria Lucia Brito et al. Guillain–Barré syndrome, acute disseminated encephalomyelitis and encephalitis associated with Zika virus infection in Brazil: detection of viral RNA and isolation of virus during late infection. The American journal of tropical medicine and hygiene, v. 97, n. 5, p. 1405, 2017. | en_US |
| ISSN | 1476-1645 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68532 | |
| Language | eng | en_US |
| Publisher | The american journal of tropical medicine and hygiene | en_US |
| Rights | open access | en_US |
| Title | Guillain-Barré Syndrome, Acute Disseminated Encephalomyelitis and Encephalitis Associated with Zika Virus Infection in Brazil | en_US |
| Type | Article | en_US |
| DOI | 10.4269/ajtmh.17-0106 | |
| Abstract | Zika virus (ZIKV) emerged in Brazil in 2015, which was followed by an increase of Guillain–Barre Syndrome (GBS)cases. We report the epidemiological, clinical, and laboratory findings of the first six neurological cases associated with ZIKVinBrazil seen in a reference neurology hospital in Pernambuco,Brazil. In allcases, ZIKV was detected in serum and/or cerebros pinal fluid(CSF) samples. In this case series, four cases were defined as GBS, one as acuted isseminated encephalomyelitis (ADEM) and the other as encephalitis. ZIKV was detected in all cases by RT-PCR and virus isolation was successful in two patients. The time between ZIKV acute symptoms and the development of neurological mani
festations varied from 3 to 13 days and ZIKV was detected between 15 and 34 days after the initial symptoms. Our results high light the need to include ZIKV as a differential diagnosis for neurological syndromes in countries with circulation of this arbovirus. Because the viremia in thesepatients appearstopersist longer, direct diagnostic techniques such as RT-PCR
and viral isolation should be considered even if it is after the acute phase of viral infection. | en_US |
| Affilliation | Department of Neurology-Hospital of Restoration. Recife, PE, Brasil. | en_US |
| Affilliation | Department of Medicine-Federal University of Pernambuco. Recife, PE, Brasil. | en_US |
| Affilliation | Department of Neurology-Hospital of Restoration. Recife, PE, Brasil. | en_US |
| Affilliation | Department of Neurology-Hospital of Restoration. Recife, PE, Brasil. | en_US |
| Affilliation | Department of Pediatrics-Hospital of Restoration. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | en_US |
