| Author | Penna, Gerson Oliveira | |
| Author | Pontes, Maria Araci de Andrade | |
| Author | Talhari, Sinésio | |
| Author | Gonçalves, Heitor de Sá | |
| Author | Talhari, Carolina | |
| Author | Pessoa, Allen de Souza | |
| Author | Pedroza, Valderiza | |
| Author | Bührer-Sékula, Samira | |
| Author | Stefani, Mariane Martins de Araujo | |
| Author | Penna, Maria Lucia Fernandes | |
| Access date | 2025-02-25T22:40:07Z | |
| Available date | 2025-02-25T22:40:07Z | |
| Document date | 2024 | |
| Citation | PENNA, Gerson Oliveira et al. Late relapses in leprosy patients in Brazil: 10-year post-trial of uniform multidrug therapy (U-MDT/CT-BR). The Brazilian Journal of Infectious Diseases, [s.l.], v. 28, n. 2, p. 1-8, mar./apr. 2024. | en_US |
| ISSN | 1413-8670 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68725 | |
| Sponsorship | Department of Science and Technology (DECIT) of Brazilian Ministry of Health and the Brazilian Council for Research (CNPq process #403293/2005-7). MMAS is a PVN-II
Research Fellow from FAPEAM/Amazonas (“Programa de Apoio a Formação em Ciências Dermatológicas − PRODERMRH, FUHAM, Manaus, Amazonas grant 010/2023). | en_US |
| Language | eng | en_US |
| Publisher | Elsevier | en_US |
| Rights | open access | en_US |
| MeSH | Leprosy | en_US |
| MeSH | Recurrence | en_US |
| Title | Late relapses in leprosy patients in Brazil: 10-year post-trial of uniform multidrug therapy (U-MDT/CT-BR) | en_US |
| Type | Article | en_US |
| DOI | 10.1016/j.bjid.2024.103745 | |
| Abstract | Background: Leprosy is a neglected dermato-neurologic, infectious disease caused by Mycobacterium leprae or M. lepromatosis. Leprosy is treatable and curable by multidrug therapy/
MDT, consisting of 12 months rifampicin, dapsone and clofazimine for multibacillary/MB
patients and for 6 months for paucibacillary/PB patients. The relapse rate is considered a
crucial treatment outcome. A randomized Controlled Clinical Trial (U-MDT/CT-BR) conducted from 2007‒2012 compared clinical outcomes in MB patients after 12 months regular
MDT/R-MDT and 6 months uniform MDT/U-MDT in two highly endemic Brazilian areas.
Objectives: To estimate the 10 years relapse rate of MB patients treated with 6 months
U-MDT.
Methods: The statistical analyses treated the data as a case-control study, sampled from
the cohort generated for the randomized trial. Analyses estimated univariate odds
ratio and applied logistic regression for multivariate analysis, controlling the confounding variables.
Results: The overall relapse rate was 4.08 %: 4.95 % (16 out of 323) in the U-MDT group and
3.10 % (9 out of 290) in the regular/R-MDT group. The difference in relapse proportion
between U-MDT and R-MDT groups was 1.85 %, not statistically significant (Odds
Ratio = 1.63, 95 % CI 0.71 to 3.74). However, misdiagnosis of relapses, may have introduced
bias, underestimating the force of the association represented by the odds ratio. Conclusions: The relapse estimate of 10 years follow-up study of the first randomized, controlled study on U-MDT/CT-BR was similar to the R-MDT group, supporting strong evidence
that 6 months U-MDT for MB patients is an acceptable option to be adopted by leprosy
endemic countries worldwide. | en_US |
| Affilliation | Universidade de Brasília. Núcleo de Medicina Tropical. Brasília, DF, Brazil / Fundação Oswaldo Cruz. Escola de Governo Fiocruz Brasília. Brasília, DF, Brazil. | en_US |
| Affilliation | Centro de Referência em Dermatologia Dona Libânia. Fortaleza, CE, Brazil. | en_US |
| Affilliation | Fundação Hospitalar de Dermatologia Tropical e Venereologia Alfredo da Matta. Manaus, AM, Brazil. | en_US |
| Affilliation | Centro de Referência em Dermatologia Dona Libânia. Fortaleza, CE, Brazil. | en_US |
| Affilliation | Fundação Hospitalar de Dermatologia Tropical e Venereologia Alfredo da Matta. Manaus, AM, Brazil. | en_US |
| Affilliation | Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas a Dermatologia. Manaus, AM, Brazil. | en_US |
| Affilliation | Fundação Hospitalar de Dermatologia Tropical e Venereologia Alfredo da Matta. Manaus, AM, Brazil. | en_US |
| Affilliation | Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brazil. | en_US |
| Affilliation | Universidade Federal Fluminense. Departamento de Epidemiologia e Bioestatística. Rio de Janeiro, RJ, Brazil. | en_US |
| Subject | Leprosy | en_US |
| Subject | Relapse | en_US |
| Subject | Clinical trial | en_US |
| Subject | Uniform multidrug therapy | en_US |
| DeCS | Hanseníase | en_US |
| DeCS | Recidiva | en_US |
| DeCS | Ensaio Clínico | en_US |
| DeCS | Tratamento Farmacológico | en_US |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
