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INTEGRATED SEROPREVALENCE AND GENOME-BASED STUDY OF SARS-COV-2 VIRAL STRAINS IN N'DJAMENA: INSIGHTS INTO CHAD'S COVID-19 EPICENTER
Hota, Mathiew et al. | Date Issued: 2025
Author
Hota, Mathiew
Wondeu, Andrillene L. D.
Abakar, Mahamat F.
Dezoumbe, Koutaya
Abdelrazakh, Fatima
Atturo, Sabrina
Naïbeï, Nathan
Cappelli, Giulia
Mennechet, Franck
Yandai, Fissou H.
Abdallah, Djamal H.
Edgard, Zongo R. F.
Boukar, Abdoulaye
Moussa, Choroma A.
Yaya, Issa M.
Hamad, Mahamat I.
Armand, Nontegyol
Honorine, Netalar
Frederic, Kayanlengar
Moustapha, Adam A.
Daniel, Yanda M.
Alim, Adam M.
Grene, Mahamat
Djarma, Oumaima
Suitombaye, Noubaramadji Y.
Akouya, Amine
Choua, Ouchemi
Dzomo, Guy R. T.
Djimtoïbaye, Djallaye
Colizzi, Vittorio
Moussa, Mahamat A.
Giovanetti, Marta
Affilliation
Department of Laboratories. Ministry of Public Health. N'Djamena, Chad.
LAGET Major Tropical Epidemics Laboratory. Bon Samaritain University Hospital. N'Djamena, Chad. / Evangelical University of Cameroon. Bandjoun, Cameroon.
Institut de Recherche en Elevage pour le Développement. N'Djamena, Chad.
LAGET Major Tropical Epidemics Laboratory. Bon Samaritain University Hospital. N'Djamena, Chad.
Institut de Recherche en Elevage pour le Développement. N'Djamena, Chad.
LAGET Major Tropical Epidemics Laboratory. Bon Samaritain University Hospital. N'Djamena, Chad. / MAGIS Foundation. N'Djamena, Chad.
Community of Friends of Computing for Development “CAID‐Tchad. N'Djamena, Chad.
Institute for Biological Systems. Monterotondo, Italy.
University of Montpellier. Pathogenesis and Control of Chronic an Emerging Infections. French Blood Establishment. Montpellier, France.
Department of Laboratories. Ministry of Public Health. N'Djamena, Chad.
Department of Laboratories. Ministry of Public Health. N'Djamena, Chad.
OMS Tchad, Assistant Laboratoire COVID ‐19, N'Djamena, Chad.
King Faycal Hospital N'Djamena. N'Djamena, Chad.
Abeché University Hospital Laboratory. Abeché, Chad.
PMTCT/HIV Bol Health District. N'Djamena, Chad.
Biltine Provincial Hospital. Biltine, Chad.
Doba Provincial Hospital. Doba, Chad.
Moundou Provincial Hospital. Moundou, Chad.
Sarh Provincial Hospital. Sarh, Chad.
Ati Provincial Hospital. Ati, Chad.
Bongor Provincial Hospital. Bongor, Chad.
Pala Provincial Hospital. Pala, Chad.
Mongo Provincial Hospital. Mongo, Chad.
Department of Infectious Diseases/National University Hospital of Reference. Université Bon Samaritain. N'Djamena, Chad.
LAGET Major Tropical Epidemics Laboratory. Bon Samaritain University Hospital. N'Djamena, Chad.
LAGET Major Tropical Epidemics Laboratory. Bon Samaritain University Hospital. N'Djamena, Chad.
Faculty of Human Health Sciences. N'djamena University. N'djamena, Chad / National University Hospital of Reference, N'Djamena, Chad.
Le Bon Samaritain University Hospital Complex. N'Djamena, Chad.
LAGET Major Tropical Epidemics Laboratory. Bon Samaritain University Hospital. N'Djamena, Chad.
Evangelical University of Cameroon. Bandjoun, Cameroon / Chantal Biya International Reference Center for Research on HIV/AIDS Prevention and Management. Yaoundé, Cameroon / University of Rome “Tor Vergata”. Rome, Italy.
Faculty of Human Health Sciences. N'djamena University. N'djamena, Chad / National University Hospital of Reference, N'Djamena, Chad.
Department of Sciences and Technologies for Sustainable Development and One Health. Università Campus Bio‐Medico di Roma. Roma, Italy. / Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil / Climate Amplified Diseases And Epidemics. Belo Horizonte, MG, Brasil.
Abstract
The COVID‐19 epidemic has shown regional variations in transmission and outcomes. As a primary hotspot in Chad, N'Djamena is crucial for comprehensive epidemiological investigation. Our study employed two methodologies: seroprevalence data collection and whole‐genome sequencing of SARS‐CoV‐2 strains. This dual approach assessed population exposure and vírus genetic diversity. Seroprevalence data indicated broader exposure than confirmed cases suggested, and genome sequencing identified multiple strains, including globally recognized variants of concern. Integrating these data provided insights into transmission dynamics, potential herd immunity thresholds, and the impact of specific variants on disease progression. Our findings underscore the importance of integrated, multidisciplinary research in infectious disease epidemiology and inform targeted public health strategies, including social measures and vaccination, to combat infectious diseases in N'Djamena.
Keywords
Chad
Genomic surveillance
SARS‐CoV‐2
Seroprevalence
 
Publisher
Willey
Citation
HOTA, Mathiew et al. Integrated seroprevalence and genome‐based study of SARS‐COV‐2 viral strains in N′Djamena: insights intochad's COVID‐19 epicenter. Journal of Medical Virology, v. 97, p. 1-10, Feb. 2025.
DOI
10.1002/jmv.70234
ISSN
0146-6615