| Author | Santos, Clarice Alves dos | |
| Author | Maia, Helena Maria Silveira Fraga | |
| Author | Pitanga, Francisco José Gondim | |
| Author | Almeida, Maria da Conceição Chagas de | |
| Author | Fonseca, Maria de Jesus Mendes da | |
| Author | Aquino, Estela Maria Motta Lima Leão de | |
| Author | Cardoso, Letícia de Oliveira | |
| Author | Griep, Rosane Härter | |
| Author | Barreto, Sandhi Maria | |
| Author | Suemoto, Claudia Kimie | |
| Author | Lotufo, Paulo Andrade | |
| Author | Bensenor, Isabela Judith Martins | |
| Author | Matos, Sheila Maria Alvim de | |
| Access date | 2025-02-28T13:57:07Z | |
| Available date | 2025-02-28T13:57:07Z | |
| Document date | 2025 | |
| Citation | SANTOS, Clarice Alves dos et al. Hand grip strength cut-off points as a discriminator of sarcopenia and sarcopenic obesity: results from the ELSA-Brasil cohort. Journal of Cachexia, Sarcopenia and Muscle, v. 16, n. 1, p. 1-13, 18 Feb. 2025. | |
| ISSN | 2190-5991 | |
| URI | https://www.arca.fiocruz.br/handle/icict/68775 | |
| Description | Produção científica do Laboratório de Educação em Ambiente e Saúde. | pt_BR |
| Sponsorship | This study was funded by the Brazilian Ministry of Health (Science and Technology Department) and the Brazilian Ministry of Science, Technology and Innovation (FINEP and CNPq): Grant Numbers: 01 06 0010.00 and 01.10.0643.03 (RS); 01 06 0212.00 and 01.10.0742-00 (BA); 01 06 0300.00 and 01.12.0284.00 (ES); 01 06 0278.00 and 01 10 0746 00 (MG); 01 06 0115.00 and 01.10.0773-00 (SP); and 01 06 0071.00 and 01.11.0093.01 (RJ). | |
| Language | eng | en_US |
| Publisher | Wiley | |
| Rights | open access | |
| Title | Hand grip strength cut-off points as a discriminator of sarcopenia and sarcopenic obesity: results from the ELSA-Brasil cohort | en_US |
| Type | Article | |
| DOI | 10.1002/jcsm.13723 | |
| Abstract | Background: Hand grip strength (HGS) may represent an epidemiologically relevant alternative as an initial screening tool for sarcopenia and sarcopenic obesity. However, no study evaluated the performance capacity of HGS compared to other biomarkers in discriminating these conditions in adults. Objective: The study aimed to evaluate the performance of HGS as discriminator of sarcopenia and sarcopenic obesity, compared to urinary biomarkers of creatinine and potassium in 24 h for Brazilian adults. Methods: Cross-sectional study. Women (n = 5431) and men (n = 6351) aged 38–79 years who participated in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) at second follow-up of the cohort (2012–2014). The area under the receiver operating characteristic curve (AUC) and the respective 95% confidence intervals were calculated for men and women in different age groups to assess the performance of HGS as a discriminator of sarcopenia and sarcopenic obesity, compared to the biomarkers of potassium and creatinine in urine in 24 h. The outcomes were classified based on the skeletal muscle mass index (BMI/height²) and fat percentage, estimated from the bioimpedance analysis data. Sensitivity, specificity and Brier score were calculated for each estimated HGS cut-off point. Results: It can be observed that 18.20% (15.51% women; 21.34% men) of the population showed a decline in skeletal muscle mass (sarcopenia). Of this total, 11.61% (10.52% women; 12.89% men) presented the isolated outcome of sarcopenia and 6.59% (4.99% women; 8.45% men) of sarcopenic obesity. The HGS areas under the ROC Curve ranged from 0.54 (CI = 0.493–0.596) to 0.76 (CI = 0.650–0.878) according to sex and age group. HGS performance compared to biomarkers was significantly higher in virtually all strata and outcomes analysed. The cut-off points that demonstrated greater accuracy and better performance in outcome discrimination were ≤ 42, ≤ 41, ≤ 38 and ≤ 36 kgf among males aged 38–44 years, 45–54 years, 55–64 years and 65–79 years, respectively. For women in the same age groups, HGS cut-offs were ≤ 26, ≤ 23, ≤ 23 and ≤ 21 kgf, respectively. Conclusions: The results suggest that HGS is a good discriminator of sarcopenia and sarcopenic obesity, capable of achieving superior or equal performance to muscle mass biomarkers, especially in middle-aged adults. | en_US |
| Affilliation | Universidade Estadual do Sudoeste da Bahia. Departamento de Ciências Biológicas. Jequié, BA, Brasil. | |
| Affilliation | Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil. | |
| Affilliation | Universidade Federal da Bahia. Faculdade de Educação. Departamento de Educação Física. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil. | |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Departamento de Clínica Médica. Divisão de Geriatria. São Paulo, SP, Brasil / Universidade de São Paulo. Faculdade de Medicina. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | |
| Affilliation | Universidade de São Paulo. Faculdade de Medicina. Hospital Universitário. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | |
| Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | |
| Subject | Diagnostic tests | en_US |
| Subject | Muscular strength | en_US |
| Subject | Musculoskeletal diseases | en_US |
| Subject | Obesity | en_US |
| Subject | Sarcopenia | en_US |
| e-ISSN | 2190-6009 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
| xmlui.metadata.dc.subject.ods | 10 Redução das desigualdades | |
