| Author | Siqueira-e-Silva, Beatriz Nogueira | |
| Author | Sousa, Luciana Pereira de | |
| Author | Rosa-Gonçalves, Pamela | |
| Author | Silva, Rízia Maria da | |
| Author | Martins, Yuri Chaves | |
| Author | Brasil, Patrícia | |
| Author | Daniel-Ribeiro, Cláudio Tadeu | |
| Access date | 2025-03-09T23:07:38Z | |
| Available date | 2025-03-09T23:07:38Z | |
| Document date | 2025 | |
| Citation | SIQUEIRA-E-SILVA, Beatriz Nogueira et al. Non-cerebral malaria: does such a thing exist? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 120, p. 1-5, Feb. 2025. | en_US |
| ISSN | 0074-0276 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/68849 | |
| Sponsorship | CTDR and PB are supported by the CNPq (grants nº 310445/2017-5 and 311562/2021-3) through a Productivity Research Fellowship, and receive a Cientista do Nosso Estado fellowship by the FAPERJ (E-26/202.921/2018 and E-26/200.935/2022), BNSS receives a PhD fellowship from CNPq (141192/2023-2), LPSV (E-26/205.722/2022), and PRG (E-26/203.039/2023) receive a FAPERJ Post-Doctoral and PhD fellowships, respectively. The Laboratório de Pesquisa em Malária (LPM-IOC, Fiocruz) is an Associate Laboratory of the Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação of the CNPq (INCT-NIM/CNPq Project 465489/2014-1) and of the Rede de Neuroinflamação da FAPERJ (Redes/FAPERJ, Project 26010.002418/2019) and receives financial support of the FAPERJ (Project SEI-260003/001169/2020). YCM receives grant support from the Saint Louis University School of Medicine, Department of Anesthesiology. BNSS, LPS and PR-G, on the one hand, and PB and YCM, on the other, contributed equally to this work. | en_US |
| Language | eng | en_US |
| Publisher | Fiocruz/IOC | en_US |
| Rights | open access | en_US |
| Title | Non-cerebral malaria: does such a thing exist? | en_US |
| Type | Article | en_US |
| DOI | 10.1590/0074-02760240223 | |
| Abstract | Malaria, caused by Plasmodium spp., remains a major public health problem. Cerebral malaria is its deadliest form, with a 15-25% mortality rate, despite artemisinin-based treatments. In addition, the World Health Organization (WHO) strictly defines cerebral malaria as the presence of coma, 1 h after a seizure or the correction of hypoglycemia, in patients with P. falciparum parasitemia. Consequently, 25% of survivors experience neurocognitive and behavioral sequelae, particularly in children. However, more recently, neurocognitive and behavioral impairments were also reported in severe non-cerebral malaria, non-severe malaria, and even during asymptomatic Plasmodium infection. Such impairments have been observed in school-aged children, the elderly, and in animal models without classic cerebral malaria pathology. Additionally, mild vasogenic edema has been detected in neuroimaging of patients with severe non-cerebral and non-severe P. falciparum malaria. Therefore, given that approximately 98% of malaria cases in the world are non-severe, neurocognitive and behavioral sequelae may account for a significant proportion of global malaria morbidity. Taken together, these observations suggest that systemic inflammation from malaria, even without traditional cerebral malaria signs, can disrupt brain function and lead to long-term sequelae. We propose that the current definition of cerebral malaria may not fully capture the observed evidence and a new conceptualization is necessary to encompass these findings. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio Grande do Norte. Centro de Biociências. Departamento de Microbiologia e Parasitologia. Natal, RN, Brasil. | en_US |
| Affilliation | Saint Louis University School of Medicine. Department of Anesthesiology. Saint Louis, MO, USA. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Treinamento em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
| Subject | Brain changes | en_US |
| Subject | Cerebral malaria | en_US |
| Subject | Cognitive and behavioral dysfunction | en_US |
| Subject | Experimental malaria | en_US |
| Subject | Non-cerebral malaria | en_US |
| Subject | Systemic inflammation | en_US |
| e-ISSN | 1678-8060 | |
