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LEPTOSPIROSIS, MELIOIDOSIS, AND RICKETTSIOSES IN THE VICIOUS CIRCLE OF NEGLECT
Tshokey, Tshokey et al. | Date Issued: 2025
Author
Tshokey, Tshokey
Ko, Ablert I.
Currie, Bart J.
Zanzi, Claudia Munoz
Goarant, Cyrille
Paris, Daniel H.
Dance, David A. B.
Limmathurotsakul, Direk
Birnie, Emma
Bertherat, Eric
Gongal, Gyanendra
Benschop, Jackie
Savelkoel, Jelmer
Stenos, John
Saraswati, Kartika
Robinson, Matthew T.
Day, Nicholas P. J.
Graves, Stephen R.
Belmain, Steven R.
Blacksell, Stuart D.
Wiersinga, Willem J.
Affilliation
Australian Rickettsial Reference Laboratory. University Hospital Geelong. Geelong, Australia / Department of Pathology and Laboratory Medicine. Jigme Dorji Wangchuck National Referral Hospital. Thimphu, Bhutan.
Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, Connecticut, United States of America / Fundação Oswaldo Cruz. Instituto Gonçlo Moniz. Salvador, BA, Brasil.
Menzies School of Health Research. Charles Darwin University and Royal Darwin Hospital. Darwin, Australia.
Division of Environmental Health Sciences. School of Public Health. University of Minnesota. Minneapolis, Minnesota, United States of America.
The Pacific Community. Public Health Division. Noumea, New Caledonia.
Department of Medicine. Swiss Tropical and Public Health Institute. Allschwil, Switzerland / Department of Clinical Research. University of Basel. Basel, Switzerland.
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit. Microbiology Laboratory. Mahosot Hospital. Vientiane, Lao People’s Democratic Republic / Faculty of Infectious and Tropical Diseases. London School of Hygiene and Tropical Medicine. London, United Kingdom.
Mahidol Oxford Tropical Medicine Research Unit. Faculty of Tropical Medicine. Mahidol University. Bangkok, Thailand and Centre for Tropical Medicine and Global Health. Nuffield Department of Medicine. University of Oxford. Oxford, United Kingdom / Department of Tropical Hygiene. Faculty of Tropical Medicine. Mahidol University. Bangkok, Thailand / Centre for Tropical Medicine and Global Health. Nuffield Department of Medicine. University of Oxford. Oxford, United Kingdom.
Center for Infection and Molecular Medicine. Amsterdam UMC location University of Amsterdam. Amsterdam, the Netherlands / Division of Infectious Diseases, Department of Medicine. Amsterdam UMC location University of Amsterdam. Amsterdam, the Netherlands.
Groupe d’Intervention en Santé Publique. Marseille, France.
World Health Emergency Programme, WHO Regional Office for South-East Asia, New Delhi, India.
Tāwharau Ora, School of Veterinary Science. Massey University. Palmerston North, New Zealand.
Center for Infection and Molecular Medicine. Amsterdam UMC location University of Amsterdam. Amsterdam, the Netherlands.
Australian Rickettsial Reference Laboratory. University Hospital Geelong. Geelong, Australia.
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Republic of Singapore / Oxford University Clinical Research Unit Indonesia. Faculty of Medicine. Universitas Indonesia. Jakarta, Indonesia.
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit. Microbiology Laboratory. Mahosot Hospital. Vientiane, Lao People’s Democratic Republic / Centre for Tropical Medicine and Global Health. Nuffield Department of Medicine. University of Oxford. Oxford, United Kingdom.
Mahidol Oxford Tropical Medicine Research Unit. Faculty of Tropical Medicine. Mahidol University. Bangkok, Thailand and Centre for Tropical Medicine and Global Health. Nuffield Department of Medicine. University of Oxford. Oxford, United Kingdom.
Australian Rickettsial Reference Laboratory. University Hospital Geelong. Geelong, Australia.
Natural Resources Institute. University of Greenwich. London, United Kingdom.
Mahidol Oxford Tropical Medicine Research Unit. Faculty of Tropical Medicine. Mahidol University. Bangkok, Thailand and Centre for Tropical Medicine and Global Health. Nuffield Department of Medicine. University of Oxford. Oxford, United Kingdom.
Center for Infection and Molecular Medicine. Amsterdam UMC location University of Amsterdam. Amsterdam, the Netherlands / Division of Infectious Diseases, Department of Medicine. Amsterdam UMC location University of Amsterdam. Amsterdam, the Netherlands.
Abstract
The global priorities in the field of infectious diseases are constantly changing. While emerging viral infections have regularly dominated public health attention, which has only intensified after the COVID-19 pandemic, numerous bacterial diseases have previously caused, and continue to cause, significant morbidity and mortality—deserving equal attention. Three potentially life-threatening endemic bacterial diseases (leptospirosis, melioidosis, and rickettsioses) are a huge public health concern especially in low- and middle-income countries. Despite their continued threat, these diseases do not receive proportionate attention from global health organizations and are not even included on the WHO list of neglected tropical diseases (NTDs). This, in turn, has led to a vicious circle of neglect with continued, yet conceivably preventable, hospitalizations and deaths each year especially in the vulnerable population. This is a call from a group of multi-institutional experts on the urgent need to directly address the circle of neglect and raise support in terms of funding, research, surveillance, diagnostics, and therapeutics to alleviate the burden of these 3 diseases.
Keywords
Leptospirosis
Melioidosis
Global health
Infectious disease epidemiology
Neglected tropical diseases
 
DeCS
Leptospirose
Melioidose
Saúde global
Doenças negligenciadas
 
Publisher
Public Library of Science
Citation
TSHOKEY, Tshokey et al. Leptospirosis, melioidosis, and rickettsioses in the vicious circle of neglect. Plos Neglected Tropical Diseases, v. 19, n. 1, p. 1-5, 2025.
DOI
10.1371/journal.pntd.0012796
ISSN
1935-2735