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https://www.arca.fiocruz.br/handle/icict/69182
BUILDING A GROWING GENOMIC REPOSITORY FOR MATERNAL AND FETAL HEALTH THROUGH THE PING CONSORTIUM
Author
Abdelmalek, Clara M.
Singh, Shriya
Fasil, Blain
Horvath, Allison R.
Mulkey, Sarah B.
Curé, Carlos
Campos, Maribel
Cavalcanti, Denise P.
Tong, Van T.
Mercado, Marcela
Daza, Marcela
Benavides, Mónica Marcela
Acosta, Jacqueline
Gilboa, Suzanne
Valencia, Diana
Sancken, Christina L.
Newton, Suzanne
Scalabrin, Deolinda M. F.
Pinhata, Marisa M. Mussi
Vasconcelos, Zilton
Chakhtoura, Nahida
Moye, Jack
Leslie, Elizabeth J.
Bulas, Dorothy
Vezina, Gilbert
Marques, Fernanda J. P.
Leyser, Marcio
Campo, Miguel Del
Vilain, Eric
DeBiasi, Roberta L.
Wang, Tongguang
Nath, Avindra
Haydar, Tarik
Muenke, Max
Mansour, Tamer A.
Plessis, Adre J. du
Murray, Jeffrey C.
Cordero, José F.
Kousa, Youssef A.
Singh, Shriya
Fasil, Blain
Horvath, Allison R.
Mulkey, Sarah B.
Curé, Carlos
Campos, Maribel
Cavalcanti, Denise P.
Tong, Van T.
Mercado, Marcela
Daza, Marcela
Benavides, Mónica Marcela
Acosta, Jacqueline
Gilboa, Suzanne
Valencia, Diana
Sancken, Christina L.
Newton, Suzanne
Scalabrin, Deolinda M. F.
Pinhata, Marisa M. Mussi
Vasconcelos, Zilton
Chakhtoura, Nahida
Moye, Jack
Leslie, Elizabeth J.
Bulas, Dorothy
Vezina, Gilbert
Marques, Fernanda J. P.
Leyser, Marcio
Campo, Miguel Del
Vilain, Eric
DeBiasi, Roberta L.
Wang, Tongguang
Nath, Avindra
Haydar, Tarik
Muenke, Max
Mansour, Tamer A.
Plessis, Adre J. du
Murray, Jeffrey C.
Cordero, José F.
Kousa, Youssef A.
Affilliation
Center for Genetic Medicine. Children’s National Research Institute. Washington, DC, USA / Honors College. University of Maryland. College Park, MD, USA.
Center for Genetic Medicine. Children’s National Research Institute. Washington, DC, USA / Honors College. University of Maryland. College Park, MD, USA.
Center for Genetic Medicine. Children’s National Research Institute. Washington, DC, USA / Honors College. University of Maryland. College Park, MD, USA.
Center for Genetic Medicine. Children’s National Research Institute. Washington, DC, USA / Center for Neuroscience Research. Children’s National Research Institute. Washington, DC, USA.
Departments of Neurology. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Departments of Pediatrics. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Prenatal Pediatrics Institute. Children’s National Hospital. Washington, DC, USA.
BIOMELab. Barranquilla, Colombia.
Center for Community Outreach for Health Across the Lifespan. Dental and Craniofacial Genomics Core. Medical Sciences Campus. University of Puerto Rico. San Juan, Puerto Rico
Universidade de Campinas. Departamento de Medicina Translacional, Genética Médica. Programa de Genética Perinatal. Campinas, SP, Brasil.
Division of Birth Defects and Infant Disorders. Centers for Disease Control and Prevention. Atlanta, GA, USA.
Facultad de Ciencias de la Salud. Universidad del Norte. Barranquilla, Colombia.
Universidad Nacional de Colombia. Bogotá, Colombia.
Instituto Nacional de Salud. Bogotá, Colombia.
Vysnova Partners, Inc. Landover, MD, USA.
Division of Birth Defects and Infant Disorders. Centers for Disease Control and Prevention. Atlanta, GA, USA.
Division of Preparedness and Emerging Infections. Centers for Disease Control and Prevention. Atlanta, GA, USA.
Division of Birth Defects and Infant Disorders. Centers for Disease Control and Prevention. Atlanta, GA, USA.
Division of Birth Defects and Infant Disorders. Centers for Disease Control and Prevention. Atlanta, GA, USA.
Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.
Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Pediatria. Ribeirão Preto, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development. National Institutes of Health. Bethesda, MD, USA.
Maternal and Pediatric Infectious Disease Branch. Eunice Kennedy Shriver National Institute of Child Health and Human Development. National Institutes of Health. Bethesda, MD, USA.
Department of Human Genetics. Emory University School of Medicine. Atlanta, GA, USA.
Department of Radiology. George Washington University School of Medicine and Health Sciences. Washington, DC, USA.
Department of Radiology. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Division of Neuroradiology at Children’s National Hospital. George Washington University School of Medicine and Health Sciences. Washington, DC, USA.
Rede SARAH de Hospitais de Reabilitação. Rio de Janeiro, RJ, Brasil.
Stead Family Department of Pediatrics. University of Iowa. Iowa City, IA, USA.
Department of Pediatrics. Division of Genetics. University of California. San Diego and Rady Children’s Hospital-San Diego. San Diego, California, USA.
Institute for Clinical and Translational Science. University of California. Irvine, CA, USA.
Division of Pediatric Infectious Diseases. Children’s National Hospital. Washington, DC, USA / Department of Microbiology. Immunology and Tropical Medicine. George Washington University School of Medicine and Health Sciences. Washington, DC, USA.
Translational Neuroscience Center. National Institute of Neurological Disorders and Stroke. National Institutes of Health. Bethesda, MD, USA.
Translational Neuroscience Center. National Institute of Neurological Disorders and Stroke. National Institutes of Health. Bethesda, MD, USA / Section of Infections of the Nervous System. National Institute of Neurological Disorders and Stroke. National Institutes of Health. Bethesda, MD, USA.
Center for Neuroscience Research. Children’s National Research Institute. Washington, DC, USA.
National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Department of Population Health and Reproduction, University of California, Davis, CA, USA / Department of Clinical Pathology. College of Medicine, Mansoura University. Mansoura, Egypt.
Departments of Neurology. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Departments of Pediatrics. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Prenatal Pediatrics Institute. Children’s National Hospital. Washington, DC, USA.
Stead Family Department of Pediatrics. University of Iowa. Iowa City, IA, USA.
Department of Epidemiology and Biostatistics. College of Public Health. University of Georgia. Athens, GA, USA.
Center for Genetic Medicine. Children’s National Research Institute. Washington, DC, USA / Honors College. University of Maryland. College Park, MD, USA / Center for Neuroscience Research. Children’s National Research Institute. Washington, DC, USA / Departments of Neurology. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Departments of Pediatrics. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Prenatal Pediatrics Institute. Children’s National Hospital. Washington, DC, USA / Division of Neurology. Children’s National Hospital. Washington, DC, USA / Neonatal Neurology Program. Children’s National Hospital. Washington, DC, USA / Division of Neurophysiology. Epilepsy, and Critical Care. Children’s National Hospital. Washington, DC, USA / Department of Genomics and Precision Medicine. George Washington University School of Medicine and Health Sciences. Washington, DC, USA.
Center for Genetic Medicine. Children’s National Research Institute. Washington, DC, USA / Honors College. University of Maryland. College Park, MD, USA.
Center for Genetic Medicine. Children’s National Research Institute. Washington, DC, USA / Honors College. University of Maryland. College Park, MD, USA.
Center for Genetic Medicine. Children’s National Research Institute. Washington, DC, USA / Center for Neuroscience Research. Children’s National Research Institute. Washington, DC, USA.
Departments of Neurology. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Departments of Pediatrics. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Prenatal Pediatrics Institute. Children’s National Hospital. Washington, DC, USA.
BIOMELab. Barranquilla, Colombia.
Center for Community Outreach for Health Across the Lifespan. Dental and Craniofacial Genomics Core. Medical Sciences Campus. University of Puerto Rico. San Juan, Puerto Rico
Universidade de Campinas. Departamento de Medicina Translacional, Genética Médica. Programa de Genética Perinatal. Campinas, SP, Brasil.
Division of Birth Defects and Infant Disorders. Centers for Disease Control and Prevention. Atlanta, GA, USA.
Facultad de Ciencias de la Salud. Universidad del Norte. Barranquilla, Colombia.
Universidad Nacional de Colombia. Bogotá, Colombia.
Instituto Nacional de Salud. Bogotá, Colombia.
Vysnova Partners, Inc. Landover, MD, USA.
Division of Birth Defects and Infant Disorders. Centers for Disease Control and Prevention. Atlanta, GA, USA.
Division of Preparedness and Emerging Infections. Centers for Disease Control and Prevention. Atlanta, GA, USA.
Division of Birth Defects and Infant Disorders. Centers for Disease Control and Prevention. Atlanta, GA, USA.
Division of Birth Defects and Infant Disorders. Centers for Disease Control and Prevention. Atlanta, GA, USA.
Department of Epidemiology of Microbial Diseases. Yale School of Public Health. New Haven, CT, USA / Ministério da Saúde. Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.
Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Pediatria. Ribeirão Preto, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development. National Institutes of Health. Bethesda, MD, USA.
Maternal and Pediatric Infectious Disease Branch. Eunice Kennedy Shriver National Institute of Child Health and Human Development. National Institutes of Health. Bethesda, MD, USA.
Department of Human Genetics. Emory University School of Medicine. Atlanta, GA, USA.
Department of Radiology. George Washington University School of Medicine and Health Sciences. Washington, DC, USA.
Department of Radiology. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Division of Neuroradiology at Children’s National Hospital. George Washington University School of Medicine and Health Sciences. Washington, DC, USA.
Rede SARAH de Hospitais de Reabilitação. Rio de Janeiro, RJ, Brasil.
Stead Family Department of Pediatrics. University of Iowa. Iowa City, IA, USA.
Department of Pediatrics. Division of Genetics. University of California. San Diego and Rady Children’s Hospital-San Diego. San Diego, California, USA.
Institute for Clinical and Translational Science. University of California. Irvine, CA, USA.
Division of Pediatric Infectious Diseases. Children’s National Hospital. Washington, DC, USA / Department of Microbiology. Immunology and Tropical Medicine. George Washington University School of Medicine and Health Sciences. Washington, DC, USA.
Translational Neuroscience Center. National Institute of Neurological Disorders and Stroke. National Institutes of Health. Bethesda, MD, USA.
Translational Neuroscience Center. National Institute of Neurological Disorders and Stroke. National Institutes of Health. Bethesda, MD, USA / Section of Infections of the Nervous System. National Institute of Neurological Disorders and Stroke. National Institutes of Health. Bethesda, MD, USA.
Center for Neuroscience Research. Children’s National Research Institute. Washington, DC, USA.
National Human Genome Research Institute. National Institutes of Health. Bethesda, MD, USA.
Department of Population Health and Reproduction, University of California, Davis, CA, USA / Department of Clinical Pathology. College of Medicine, Mansoura University. Mansoura, Egypt.
Departments of Neurology. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Departments of Pediatrics. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Prenatal Pediatrics Institute. Children’s National Hospital. Washington, DC, USA.
Stead Family Department of Pediatrics. University of Iowa. Iowa City, IA, USA.
Department of Epidemiology and Biostatistics. College of Public Health. University of Georgia. Athens, GA, USA.
Center for Genetic Medicine. Children’s National Research Institute. Washington, DC, USA / Honors College. University of Maryland. College Park, MD, USA / Center for Neuroscience Research. Children’s National Research Institute. Washington, DC, USA / Departments of Neurology. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Departments of Pediatrics. George Washington University School of Medicine and Health Sciences. Washington, DC, USA / Prenatal Pediatrics Institute. Children’s National Hospital. Washington, DC, USA / Division of Neurology. Children’s National Hospital. Washington, DC, USA / Neonatal Neurology Program. Children’s National Hospital. Washington, DC, USA / Division of Neurophysiology. Epilepsy, and Critical Care. Children’s National Hospital. Washington, DC, USA / Department of Genomics and Precision Medicine. George Washington University School of Medicine and Health Sciences. Washington, DC, USA.
Abstract
Background: Prenatally transmitted viruses can cause severe damage to the developing brain. There is unexplained variability in prenatal brain injury and postnatal neurodevelopmental outcomes, suggesting disease modifiers. Of note, prenatal Zika infection can cause a spectrum of neurodevelopmental disorders, including congenital Zika syndrome. Currently, there is no preventative treatment or cure. The Prenatal Infection and Neurodevelopmental Genetics (PING) Consortium aims to identify modulators of brain injury and adverse neurodevelopmental outcomes for Zika and other prenatal viral infections. Methods: The Consortium pools information from eight multi-site studies conducted at 23 research centers in six countries to build a growing clinical and genomic repository, which is being mined for modifiers of virally induced brain injury. Partners include Children’s National Hospital (USA), Instituto Nacional de Salud (Colombia), the Natural History of Zika Virus Infection in Gestation program (Brazil), Zika Instituto Fernandes Figueira (Brazil), the Centers for Disease Control and Prevention, and the National Institutes of Health. Results: We have enrolled 4102 mothers and 3877 infants with 3063 biological samples and clinical data covering over 80 phenotypic fields and 5000 variables. Thus far, we have performed whole exome sequencing on 1226 participants.
Conclusion: Here, we present the Consortium’s formation and overarching study design.
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