| Author | Silva, Ronaldo Celerino da | |
| Author | Cruz, Heidi Lacerda Alves da | |
| Author | Brandão, Lucas André Cavalcanti | |
| Author | Guimarães, Rafael Lima | |
| Author | Montenegro, Lilian Maria Lapa | |
| Author | Schindler, Haiana Charifker | |
| Author | Segat, Ludovica | |
| Author | Crovella, Sergio | |
| Access date | 2025-03-26T15:00:56Z | |
| Available date | 2025-03-26T15:00:56Z | |
| Document date | 2016 | |
| Citation | SILVA, R. C. da et al. DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population. Brazilian Journal of Microbiology, v. 47, n. 2, p. 389–393, Apr./Jun. 2016. | en_US |
| ISSN | 1678-4405 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/69239 | |
| Language | eng | en_US |
| Publisher | Brazilian Society for Microbiology | |
| Rights | open access | en_US |
| Title | DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population | en_US |
| Type | Article | en_US |
| DOI | 10.1016/j.bjm.2015.09.001 | |
| Abstract | β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G>A (rs1799946), -44C>G (rs1800972) and -20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50). | en_US |
| Affilliation | Department of Genetics. Federal University of Pernambuco. Recife, PE, Brazil / Laboratory of Immunopathology Keizo Asami. Federal University of Pernambuco. Recife, PE, Pernambuco, Brazil. | en_US |
| Affilliation | Department of Genetics. Federal University of Pernambuco. Recife, PE, Brazil / Laboratory of Immunopathology Keizo Asami. Federal University of Pernambuco. Recife, PE, Pernambuco, Brazil. | en_US |
| Affilliation | Department of Genetics. Federal University of Pernambuco. Recife, PE, Brazil / Laboratory of Immunopathology Keizo Asami. Federal University of Pernambuco. Recife, PE, Pernambuco, Brazil. | en_US |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil. | en_US |
| Affilliation | Institute for Maternal and Child Health - IRCCS "Burlo Garofolo". Trieste, Italy. | en_US |
| Subject | Adult | en_US |
| Subject | Aged | en_US |
| Subject | Base Sequence | en_US |
| Subject | beta-Defensins | en_US |
| Subject | Brazil | en_US |
| Subject | DEFB1 | en_US |
| Subject | Female | en_US |
| Subject | Genetic Predisposition to Disease | en_US |
| Subject | Genotype | en_US |
| Subject | Genotyping | en_US |
| Subject | Haplotypes | en_US |
| Subject | Humans | en_US |
| DeCS | Polimorfismo genético | en_US |
| DeCS | Tuberculose | en_US |
| DeCS | Brasil | en_US |
| DeCS | Humanos | en_US |
| DeCS | Feminino | en_US |
| DeCS | Imunidade Inata | en_US |
| DeCS | Técnicas de Genotipagem | en_US |
| DeCS | Haplotipos | en_US |
| DeCS | Meia-idade | en_US |
| DeCS | Dados de Sequência Molecular | en_US |
| DeCS | Predisposição Genética para Doença | en_US |
| DeCS | beta-Defensinas | en_US |
| DeCS | Sequência de Bases | en_US |
