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DEFB1 GENE POLYMORPHISMS AND TUBERCULOSIS IN A NORTHEASTERN BRAZILIAN POPULATION
Silva, Ronaldo Celerino da et al. | Date Issued: 2016
Author
Silva, Ronaldo Celerino da
Cruz, Heidi Lacerda Alves da
Brandão, Lucas André Cavalcanti
Guimarães, Rafael Lima
Montenegro, Lilian Maria Lapa
Schindler, Haiana Charifker
Segat, Ludovica
Crovella, Sergio
Affilliation
Department of Genetics. Federal University of Pernambuco. Recife, PE, Brazil / Laboratory of Immunopathology Keizo Asami. Federal University of Pernambuco. Recife, PE, Pernambuco, Brazil.
Department of Genetics. Federal University of Pernambuco. Recife, PE, Brazil / Laboratory of Immunopathology Keizo Asami. Federal University of Pernambuco. Recife, PE, Pernambuco, Brazil.
Department of Genetics. Federal University of Pernambuco. Recife, PE, Brazil / Laboratory of Immunopathology Keizo Asami. Federal University of Pernambuco. Recife, PE, Pernambuco, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo". Trieste, Italy.
Abstract
β-Defensin-1, an antimicrobial peptide encoded by the DEFB1 gene, is known to play an important role in lung mucosal immunity. In our association study we analyzed three DEFB1 functional polymorphisms -52G>A (rs1799946), -44C>G (rs1800972) and -20G>A (rs11362) in 92 tuberculosis patients and 286 healthy controls, both from Northeast Brazil: no association was found between the studied DEFB1 polymorphisms and the disease. However we cannot exclude that this lack of association could be due to the low number of subjects analyzed, as suggested by the low statistical power achieved for the three analyzed SNPs (values between 0.16 and 0.50).
Keywords
Adult
Aged
Base Sequence
beta-Defensins
Brazil
DEFB1
Female
Genetic Predisposition to Disease
Genotype
Genotyping
Haplotypes
Humans
 
DeCS
Polimorfismo genético
Tuberculose
Brasil
Humanos
Feminino
Imunidade Inata
Técnicas de Genotipagem
Haplotipos
Meia-idade
Dados de Sequência Molecular
Predisposição Genética para Doença
beta-Defensinas
Sequência de Bases
 
Publisher
Brazilian Society for Microbiology
Citation
SILVA, R. C. da et al. DEFB1 gene polymorphisms and tuberculosis in a Northeastern Brazilian population. Brazilian Journal of Microbiology, v. 47, n. 2, p. 389–393, Apr./Jun. 2016.
DOI
10.1016/j.bjm.2015.09.001
ISSN
1678-4405