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CARDIAC AND LIVER FIBROSIS ASSESSED BY MULTIPARAMETRIC MRI IN PATIENTS WITH FONTAN CIRCULATION
Author
Innocenzi, Adriana
Rangel, Isabela
Póvoa‑Corrêa, Mariana
Parente, Daniella Braz
Perez, Renata
Rodrigues, Rosana Souza
Fukuyama, Lúcia Tomoko
Barroso, Julia Machado
Oliveira Neto, Jaime Araújo
Sousa, Andréa Silvestre de
Luiz, Ronir Raggio
Barbosa, Rosa Célia Pimentel
Camargo, Gabriel Cordeiro
Moll‑Bernardes, Renata
Rangel, Isabela
Póvoa‑Corrêa, Mariana
Parente, Daniella Braz
Perez, Renata
Rodrigues, Rosana Souza
Fukuyama, Lúcia Tomoko
Barroso, Julia Machado
Oliveira Neto, Jaime Araújo
Sousa, Andréa Silvestre de
Luiz, Ronir Raggio
Barbosa, Rosa Célia Pimentel
Camargo, Gabriel Cordeiro
Moll‑Bernardes, Renata
Affilliation
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Pro Criança Cardíaca. Rio de Janeiro, RJ, Brasil / Clínica Cardiológica Infantil. Rio de Janeiro, RJ, Brasil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Macaé, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.
Pro Criança Cardíaca. Rio de Janeiro, RJ, Brasil / Clínica Cardiológica Infantil. Rio de Janeiro, RJ, Brasil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory in Chagas Disease. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.
Pro Criança Cardíaca. Rio de Janeiro, RJ, Brasil / Clínica Cardiológica Infantil. Rio de Janeiro, RJ, Brasil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Pro Criança Cardíaca. Rio de Janeiro, RJ, Brasil / Clínica Cardiológica Infantil. Rio de Janeiro, RJ, Brasil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Macaé, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.
Pro Criança Cardíaca. Rio de Janeiro, RJ, Brasil / Clínica Cardiológica Infantil. Rio de Janeiro, RJ, Brasil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory in Chagas Disease. Rio de Janeiro, RJ, Brazil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Rio de Janeiro, RJ, Brazil.
Pro Criança Cardíaca. Rio de Janeiro, RJ, Brasil / Clínica Cardiológica Infantil. Rio de Janeiro, RJ, Brasil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.
D'Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
Abstract
The abnormal hemodynamics in Fontan circulation due to persistently increased systemic venous pressure results in hepatic venous congestion and Fontan-associated liver disease. Combined assessment of cardiac and liver fibrosis and cardiac remodeling using multiparametric MRI in this context have not been fully explored. To evaluate cardiac and liver fibrosis and cardiac remodeling using multiparametric MRI in patients who have undergone Fontan procedures. Thirty-eight patients and 23 controls underwent cardiac and liver MRI examinations in a 3.0-T scanner. Mann-Whitney, Fisher exact test, and Spearman's correlation were applied to evaluate myocardial volumes, function, native cardiac and liver T1 mapping, ECVs and liver stiffness. The mean native cardiac T1 value (p = 0.018), cardiac ECV (p < 0.001), liver native T1 (p < 0.001), liver ECV (p < 0.001), and liver stiffness (p < 0.001) were higher in patients than controls. The indexed end-diastolic volume (EDVi) correlated with the myocardial ECV (r = 0.356; p = 0.033), native liver T1 (r = 0.571; p < 0.001), and with liver stiffness (r = 0.391; p = 0.015). In addition, liver stiffness correlated with liver ECV (r = 0.361; p = 0.031) and native liver T1 (r = 0.458; p = 0.004). An association between cardiac remodeling and cardiac and liver fibrosis were found in this population. The usefulness of MRI to follow cardiac and liver involvement in these patients is critical to improve treatment strategies and to prevent the need for combined liver and heart transplantation.
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